2,4-二氯-6-硝基喹唑啉合成路线 （共 12 条）
反应条件
tri(n-propyl)amine; trichlorophosphate in toluene T=20 - 110°C;
参考文献
Bembenek, Scott D.; Hocutt, Frances M.; Leonard, JR., Barry Eastman; Rabinowitz, Michael H.; Rosen, Mark D.; Tarantino, Kyle T.; Venkatesan, Hariharan
Patent: US2010/204226 A1, 2010 ;
Location in patent: Page/Page column 61 ;
反应条件
1: bis(trichloromethyl) carbonate With triethylamine; triphenyl-phosphine oxide in chlorobenzene T=20°C; 0.5 h; Cooling with ice; 2: 1-amino-2-cyano-4-nitrobenzene in chlorobenzene T=120°C; 10 h;
参考文献
Li, Zhenhua; Wu, Danli; Zhong, Weihui
Heterocycles, 2012 , vol. 85, # 6 p. 1417 - 1426
反应条件
in ice-water; trichlorophosphate
反应条件
in acetonitrile T=130°C; 12 h;
参考文献
Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon
Synlett, 2006 , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: aq. K2CO3 / methanol / 12 h / 20 °C 2: 62 percent / acetonitrile / 12 h / 130 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: dimethylformamide / 0.5 h / 20 °C 2: dimethylformamide / 0.5 h / 100 °C 3: aq. K2CO3 / methanol / 12 h / 20 °C 4: 62 percent / acetonitrile / 12 h / 130 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: dimethylformamide / 0.5 h / 100 °C 2: aq. K2CO3 / methanol / 12 h / 20 °C 3: 62 percent / acetonitrile / 12 h / 130 °C View Scheme
参考文献
Synlett, , # 1 art. no. U27905ST, p. 65 - 68
反应条件
1: 10 h / 150 °C 2: phosphorus pentachloride; trichlorophosphate / 6.5 h / Reflux View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 19, # 9 p. 2797 - 2807
