4-(四氢-吡喃-2-基氧基)-苯甲醛合成路线 （共 29 条）
反应条件
1: sodium hydroxide / methanol / 3 h / 20 °C 2: hydrogenchloride / 4 h / 20 °C View Scheme
参考文献
Leow, Pay-Chin; Bahety, Priti; Boon, Choon Pei; Lee, Chong Yew; Tan, Kheng Lin; Yang, Tianming; Ee, Pui-Lai Rachel
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 67 - 80
反应条件
1: barium hydroxide octahydrate / methanol / 12 h / 50 °C 2: p-toluenesulfonic acid / methanol / 15 h / Ambient temperature View Scheme
参考文献
Sogawa; Nihro; Ueda; Izumi; Miki; Matsumoto; Satoh
Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3904 - 3909
反应条件
silica-supported NaHSO4 in methanol T=20°C; 0.166667 h;
参考文献
Chinese Journal of Chemistry, , vol. 30, # 5 p. 1189 - 1191
反应条件
1: Et3N 2: PPTS View Scheme
参考文献
Kawatsuki, Nobuhiro; Kitani, Yuki; Oda, Akihiro
Molecular Crystals and Liquid Crystals, 2005 , vol. 441, p. 153 - 161
反应条件
1: partially dehydrated barium hydroxide octahydrate / ethanol / 2 h / Heating 2: 0.03 g / p-toluenesulfonic acid / methanol / 4 h / 20 °C 3: 67 percent / 10 percent H2SO4 / methanol / 7 h / Heating View Scheme
参考文献
Pouget; Fagnere; Basly; Besson; Champavier; Habrioux; Chulia
Pharmaceutical Research, 2002 , vol. 19, # 3 p. 286 - 291
反应条件
1: barium hydroxide octahydrate / 40 °C 2: 2.47 g / p-toluenesulfonic acid / 20 °C View Scheme
参考文献
Sogawa; Nihro; Ueda; Izumi; Miki; Matsumoto; Satoh
Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3904 - 3909
反应条件
1: Ba(OH)2*8H2O / methanol / 12 h / 40 °C 2: 3.41 g / TsOH / methanol / 4 h / 20 °C View Scheme
参考文献
Severi; Costantino; Benvenuti; Vampa; Mucci
Medicinal Chemistry Research, 1996 , vol. 6, # 2 p. 128 - 136
反应条件
boron trifluoride diethyl etherate; sodium cyanoborohydride in tetrahydrofuran 1 h; Ambient temperature;
参考文献
Srikrishna, A.; Sattigeri, J. A.; Viswajanani, R.; Yelamaggad, C. V.
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 2260
反应条件
boron trifluoride diethyl etherate; sodium cyanoborohydride in tetrahydrofuran 8 h; Ambient temperature; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Srikrishna, A.; Sattigeri, J. A.; Viswajanani, R.; Yelamaggad, C. V.
Journal of Organic Chemistry, 1995 , vol. 60, # 7 p. 2260
反应条件
potassium tert-butylate 1.) THF, -78 deg C, 30 min, 2.) THF, from -78 deg C to RT, 4 h; Yield given. Multistep reaction;
参考文献
Iguchi; Iwamura; Nishizaki; Hayashi; Senokuchi; Kobayashi; Sakaki; Hachiya; Ichioka; Kawamura
Chemical and Pharmaceutical Bulletin, 1992 , vol. 40, # 6 p. 1462 - 1469
