4-氨基-3-氰基-苯甲酸合成路线 （共 3 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran
T=20°C; 20 h;
2: With hydrogenchloride in tetrahydrofuran; water
pH=3;
参考文献
NEUROSEARCH A/S
Patent: WO2004/22529 A2, 2004 ;
Location in patent: Page 33 ;
WO 2004/022529 A2
反应条件
1: 31 percent / dimethylformamide / 21 h / 140 °C
2: 49 h / 30 °C / phosphate buffer pH 7.0, nitrilase SP 361
View Scheme
参考文献
Crosby, John; Moilliet, Jock; Parratt, Julian S.; Turner, Nicolas J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 13 p. 1679 - 1688
反应条件
T=30°C; 49 h; phosphate buffer pH 7.0, nitrilase SP 361; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Crosby, John; Moilliet, Jock; Parratt, Julian S.; Turner, Nicolas J.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1994 , # 13 p. 1679 - 1688
