1-(2-甲氧基苯基)环丙烷甲腈合成路线 （共 6 条）
反应条件
potassium hexamethylsilazane in toluene
T=75°C; Substitution; 48 h;
参考文献
Caron, Stephane; Vazquez, Enrique; Wojcik, Jill M.
Journal of the American Chemical Society, 2000 , vol. 122, # 4 p. 712 - 713
反应条件
potassium hydroxide in water; dimethyl sulfoxide
参考文献
The Boots Company PLC
Patent: US5519034 A1, 1996 ;
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium diisopropyl amide in tetrahydrofuran
参考文献
Schering Aktiengesellschaft
Patent: US6344454 B1, 2002 ;
Location in patent: Page column 15 ;
反应条件
sodium amide
1.) toluene, heating, 1 h, 2.) overnight; heating, 6 h; Yield given. Multistep reaction;
参考文献
Mndzhoyan, Sh. L.; Tsinker, M. G.; Ovakimyan, A. R.; Ter-Zakharyan, Yu. Z.; Kazaryan, E. V.; Paronikyan, R. V.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 114 - 118
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 40 - 45
反应条件
potassium hydroxide in diethylene glycol
8 h; Heating;
参考文献
Mndzhoyan, Sh. L.; Tsinker, M. G.; Ovakimyan, A. R.; Ter-Zakharyan, Yu. Z.; Kazaryan, E. V.; Paronikyan, R. V.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 2 p. 114 - 118
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 2 p. 40 - 45
参考文献
The Boots Company PLC
Patent: US5519034 A1, 1996 ;
