1-(3-甲氧基苯基)环丙烷甲腈合成路线 （共 4 条）
反应条件
tetrabutylammomium bromide; sodium hydroxide in water; toluene
T=20°C; 16 h;
参考文献
PFIZER INC.; AHN, Kay; BOEHM, Markus; CABRAL, Shawn; CARPINO, Philip A.; FUTATSUGI, Kentaro; HEPWORTH, David; KUNG, Daniel W.; ORR, Suvi; WANG, Jian
Patent: WO2013/150416 A1, 2013 ;
Location in patent: Page/Page column 78; 79 ;
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in water
T=40 - 50°C;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: WO2007/144203 A1, 2007 ;
Location in patent: Page/Page column 57; 69 ;
反应条件
potassium carbonate
T=145 - 150°C; 1 h;
参考文献
Arava, Veera Reddy; Siripalli, Udaya Bhaskara Rao; Dubey, Pramod Kumar
Tetrahedron Letters, 2005 , vol. 46, # 42 p. 7247 - 7248
反应条件
1: With potassium hydroxide in ethanol; water
5 h; Heating / reflux;
2: With hydrogenchloride in ethanol; water
pH=1 - 2;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2007/64045 A1, 2007 ;
Location in patent: Page/Page column 537-538 ;
WO 2007/064045 A1
