6-(哌啶-4-甲基)-2H-苯并[b][1,4]噁嗪-3(4h)-酮合成路线 （共 10 条）
反应条件
hydrogen; palladium on activated charcoal in methanol
T=65°C; P=2585.81 Torr; 18 h;
参考文献
WYETH
Patent: WO2008/150848 A1, 2008 ;
Location in patent: Page/Page column 100; 102 ;
WO 2008/150848 A1
反应条件
1: magnesium
2: hydrogen bromide / water
3: hydrogen; platinum(IV) oxide; sulfuric acid / methanol
4: acetic acid; nitric acid
5: triethylamine / tetrahydrofuran; water
6: potassium carbonate / acetone / |Heating
7: hydrogen; palladium on activated charcoal
8: hydrogenchloride / diethyl ether; isopropyl alcohol / |Heating
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
反应条件
1: hydrogen bromide / water
2: hydrogen; platinum(IV) oxide; sulfuric acid / methanol
3: acetic acid; nitric acid
4: triethylamine / tetrahydrofuran; water
5: potassium carbonate / acetone / |Heating
6: hydrogen; palladium on activated charcoal
7: hydrogenchloride / diethyl ether; isopropyl alcohol / |Heating
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
反应条件
1: hydrogen; palladium on activated charcoal
2: hydrogenchloride / diethyl ether; isopropyl alcohol / |Heating
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
反应条件
1: hydrogen; platinum(IV) oxide; sulfuric acid / methanol
2: acetic acid; nitric acid
3: triethylamine / tetrahydrofuran; water
4: potassium carbonate / acetone / |Heating
5: hydrogen; palladium on activated charcoal
6: hydrogenchloride / diethyl ether; isopropyl alcohol / |Heating
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
反应条件
1: acetic acid; nitric acid
2: triethylamine / tetrahydrofuran; water
3: potassium carbonate / acetone / |Heating
4: hydrogen; palladium on activated charcoal
5: hydrogenchloride / diethyl ether; isopropyl alcohol / |Heating
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
反应条件
1: triethylamine / tetrahydrofuran; water
2: potassium carbonate / acetone / |Heating
3: hydrogen; palladium on activated charcoal
4: hydrogenchloride / diethyl ether; isopropyl alcohol / |Heating
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
反应条件
1: potassium carbonate / acetone / |Heating
2: hydrogen; palladium on activated charcoal
3: hydrogenchloride / diethyl ether; isopropyl alcohol / |Heating
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
反应条件
1: magnesium
2: hydrogen bromide / water
3: hydrogen; platinum(IV) oxide; sulfuric acid / methanol
4: acetic acid; nitric acid
5: triethylamine / tetrahydrofuran; water
6: potassium carbonate / acetone / |Heating
7: hydrogen; palladium on activated charcoal
8: hydrogenchloride / diethyl ether; isopropyl alcohol / |Heating
View Scheme
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
反应条件
N-ethyl-N,N-diisopropylamine in isopropyl alcohol
Heating;
参考文献
Armitage, Mark; Bret, Guillaume; Choudary, Bernie M.; Kingswood, Mike; Loft, Mike; Moore, Steve; Smith, Steve; Urquhart, Michael W. J.
Organic Process Research and Development, 2012 , vol. 16, # 10 p. 1626 - 1634
