5-乙氧基螺[吲哚-3,4'-哌啶]-2(1H)-酮合成路线 （共 2 条）
反应条件
1: 1,3-dihydro-5-methoxy-2H-indol-2-one With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.5 h;
2: 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride T=20°C; 13.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/76455 A1, 2004 ;
Location in patent: Page 41 ;
WO 2004/076455 A1
反应条件
1: 1,3-dihydro-5-methoxy-2H-indol-2-one With sodium hexamethyldisilazane in tetrahydrofuran
T=-78°C; 0.5 h;
2: 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride in tetrahydrofuran
T=-78 - 20°C; 13.5 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2004/69256 A1, 2004 ;
Location in patent: Page/Page column 46 ;
WO 2004/069256 A1
