(1-甲基-2,2-二苯基环丙基)二叔丁基膦合成路线 (共 2 条)
反应条件
1: 1-chloro-1-methyl-2,2-diphenylcyclopropane With 1,1-dimethylethylmagnesium chloride; iodine; magnesium in tetrahydrofuran
T=65°C; Inert atmosphere;
2: chlorodi-tert-butylphosphine With copper(l) iodide; lithium bromide in tetrahydrofuran
T=55°C; 6 h; Inert atmosphere;
参考文献
Suzuki, Ken; Hori, Yoji; Kobayashi, Tohru
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 5 p. 652 - 656
反应条件
1: 1-bromo-1-methyl-2,2-diphenylcyclopropane With magnesium; iodine in tetrahydrofuran
T=40°C; 1 h;
2: chlorodi-tert-butylphosphine With copper(l) iodide; lithium bromide in tetrahydrofuran
T=60°C; 3 h; Product distribution / selectivity;
参考文献
TAKASAGO INTERNATIONAL CORPORATION
Patent: WO2004/72088 A2, 2004 ;
Location in patent: Page/Page column 45-46 ;