9H-吡啶并[3,4-b]吲哚-3-羧酸合成路线 （共 25 条）
反应条件
1: 57 percent / AcOH, Pb(OAc)4 / 15 h
2: 96 percent / NaOH / H2O; ethanol / 0.5 h / Heating
View Scheme
参考文献
Lippke; Schunack; Wenning; Muller
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 499 - 503
反应条件
1: 50 percent / DDQ / xylene / 48 h / Heating
2: 95 percent / HCl / ethanol / 24 h / 4 °C
3: 1N aq. NaOH / ethanol; H2O / 0.5 h / Heating
View Scheme
参考文献
Dellouve-Courillon; Dorey; Poissonnet; Doisy; Potier; Dodd
Tetrahedron, 1990 , vol. 46, # 9 p. 3245 - 3266
反应条件
1: 95 percent / HCl / ethanol / 24 h / 4 °C
2: 1N aq. NaOH / ethanol; H2O / 0.5 h / Heating
View Scheme
参考文献
Dellouve-Courillon; Dorey; Poissonnet; Doisy; Potier; Dodd
Tetrahedron, 1990 , vol. 46, # 9 p. 3245 - 3266
反应条件
1: triethylamine / CHCl3 / 1.) RT, 16 h, 2.) reflux, 6 h
2: 4-toluenesulfonic acid / acetonitrile / 48 h / Ambient temperature
3: triethylamine, acetic acid / methanol
4: 91 percent / aq. base
View Scheme
参考文献
Maclaren, John A.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 813 - 821
反应条件
1: triethylamine, acetic acid / methanol
2: 91 percent / aq. base
View Scheme
参考文献
Maclaren, John A.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 813 - 821
反应条件
1: 4-toluenesulfonic acid / acetonitrile / 48 h / Ambient temperature
2: triethylamine, acetic acid / methanol
3: 91 percent / aq. base
View Scheme
参考文献
Maclaren, John A.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 813 - 821
反应条件
1: 72 percent / lead tetraacetate / acetic acid
2: 91 percent / aq. base
View Scheme
参考文献
Maclaren, John A.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 813 - 821
反应条件
phosphorus; hydrogen iodide; potassium iodide
T=180°C;
参考文献
King; Stiller
Journal of the Chemical Society, 1937 , p. 466,473
反应条件
1: 64 percent / formic acid, conc. aq. HCl / 3 h / 50 °C
2: 1.) thionyl chloride, 2.) pyridinium dichromate / 1.) RT, overnight, 2.) DMF, RT, 16 h
3: 91 percent / aq. base
View Scheme
参考文献
Maclaren, John A.
Australian Journal of Chemistry, 1989 , vol. 42, # 6 p. 813 - 821
反应条件
1: P2O5; POCl3 / und Erwaermen des Reaktionsprodukts mit Methanol
2: aqueous HI; red phosphorus; KI / 180 °C
View Scheme
参考文献
King; Stiller
Journal of the Chemical Society, 1937 , p. 466,473
