反应条件
1: 1.) ethyl chloroformate, triethylamine; 2.) NaBH4 / 1.) THF, -10 deg C, 1 h; 2.) THF, H2O, 0 deg C, 0.5 h, r.t., 3.5 h 2: 1.24 g / oxalyl chloride, DMSO, Et3N / CH2Cl2 / -78 deg C, 0.5 h, 0 deg C, 2 h 3: 87 percent / NaBH3CN / methanol; tetrahydrofuran / 20 h / 0 °C 4: trimethylsilyl triflate / CH2Cl2 / 0.5 h / 0 °C 5: AcOH / methanol 6: NaBH3CN / tetrahydrofuran; methanol / 19.5 h / 0 °C 7: HCl, anisole / H2O; tetrahydrofuran / 17 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 44, # 1 p. 519 - 530
