6-氯-1,4-二羟基萘-2,3-二酮合成路线 （共 7 条）
反应条件
perchloric acid in acetic acid
T=100°C; 7 h;
参考文献
Jones, Gordon H.; Venuti, Michael C.; Young, John M.; Murthy, D.V. Krishna; Loe, Brad E.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1504 - 1511
反应条件
dihydrogen peroxide; sodium hydrogencarbonate in water
参考文献
Syntex (U.S.A.) Inc.
Patent: US4255405 A1, 1981 ;
反应条件
1: 94 percent / bleach / tetrahydrofuran / 1 h / Ambient temperature
2: 42 percent / aq. perchloric acid / acetic acid / 7 h / 100 °C
View Scheme
参考文献
Jones, Gordon H.; Venuti, Michael C.; Young, John M.; Murthy, D.V. Krishna; Loe, Brad E.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1504 - 1511
反应条件
1: 1.) HOAc, 2.) Na2Cr2O7, aq. H2SO4 / 1.) RT, 3 d, 2.) 60-65 deg C
2: 94 percent / bleach / tetrahydrofuran / 1 h / Ambient temperature
3: 42 percent / aq. perchloric acid / acetic acid / 7 h / 100 °C
View Scheme
参考文献
Jones, Gordon H.; Venuti, Michael C.; Young, John M.; Murthy, D.V. Krishna; Loe, Brad E.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1504 - 1511
反应条件
trifluoroacetic acid
0.25 h; Ambient temperature; Yield given;
参考文献
Enhsen, Alfons; Karabelas, Kostas; Heerding, Julia M.; Moore, Harold W.
Journal of Organic Chemistry, 1990 , vol. 55, # 4 p. 1177 - 1185
反应条件
1: 92 percent
2: 1) 1,8-bis(dimethylamino)naphthalene 2) Ag2O, K2CO3 / 1) xylene, reflux, 9.5 h 2) benzene, r.t., 2 h
3: TFA / 0.25 h / Ambient temperature
View Scheme
参考文献
Enhsen, Alfons; Karabelas, Kostas; Heerding, Julia M.; Moore, Harold W.
Journal of Organic Chemistry, 1990 , vol. 55, # 4 p. 1177 - 1185
反应条件
1: 1) 1,8-bis(dimethylamino)naphthalene 2) Ag2O, K2CO3 / 1) xylene, reflux, 9.5 h 2) benzene, r.t., 2 h
2: TFA / 0.25 h / Ambient temperature
View Scheme
参考文献
Enhsen, Alfons; Karabelas, Kostas; Heerding, Julia M.; Moore, Harold W.
Journal of Organic Chemistry, 1990 , vol. 55, # 4 p. 1177 - 1185
