反应条件
1: methyl 3,3-dimethoxy-propanoate; formic acid methyl ester With sodium hydride in tetrahydrofuran T=0 - 50°C; 4 h; 2: 1-methylguanidine hydrochloride in tetrahydrofuran; N,N-dimethyl-formamide T=100°C; 3 h; Inert atmosphere;
参考文献
GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling
Patent: WO2013/127268 A1, 2013 ;
Location in patent: Page/Page column 60 ;
