trifluoroacetic acid in dichloromethane T=20°C; 1 h;

in sodium hydroxide

potassium carbonate in tetrahydrofuran; water 2 h; Ambient temperature;

1: 40.6 g / DCC, NEt3 / CH2Cl2 / Ambient temperature 2: H2SO4, H2O / 2 h / 80 - 85 °C 3: 65 percent / K2CO3 / tetrahydrofuran; H2O / 2 h / Ambient temperature View Scheme

1: H2SO4, H2O / 2 h / 80 - 85 °C 2: 65 percent / K2CO3 / tetrahydrofuran; H2O / 2 h / Ambient temperature View Scheme

1: 40.6 g / DCC, NEt3 / CH2Cl2 / Ambient temperature 2: H2SO4, H2O / 2 h / 80 - 85 °C 3: 65 percent / K2CO3 / tetrahydrofuran; H2O / 2 h / Ambient temperature View Scheme

1: 95.1 percent / NaOMe / methanol; 1,2-dichloro-ethane / 1 h / Ambient temperature 2: 40.6 g / DCC, NEt3 / CH2Cl2 / Ambient temperature 3: H2SO4, H2O / 2 h / 80 - 85 °C 4: 65 percent / K2CO3 / tetrahydrofuran; H2O / 2 h / Ambient temperature View Scheme