4-溴-2-氟-6-硝基苯甲醚合成路线 （共 11 条）
反应条件
1: 49 percent / liquid nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature 2: 98.5 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr 3: 2., HBr, CuBr 4: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 175 - 178
反应条件
1: 98.5 percent / hydrogen / 5percent Pd/C / ethyl acetate / 24 h / 760 Torr 2: 2., HBr, CuBr 3: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 175 - 178
反应条件
1: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 175 - 178
反应条件
1: 2., HBr, CuBr 2: 98 percent / liquide nitrogen dioxide / pentane / 35 min, 0 deg C then 20 min, room temperature View Scheme
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 175 - 178
反应条件
Yield given. Multistep reaction;
参考文献
Bulletin de la Societe Chimique de France, , vol. 2, # 3-4 p. 175 - 178
反应条件
1: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr 3: 84 percent / 48percent HBr / 4.5 h / Heating View Scheme
参考文献
Aymes, Daniel J.; Paris, Michel R.
Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 3-4 p. 175 - 178
反应条件
potassium hydroxide; hydrogen; palladium on activated charcoal in methanol P=60004.8 - 75005.9 Torr; 1 h;
参考文献
Aymes, Daniel J.; Paris, Michel R.
Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 3-4 p. 175 - 178
反应条件
ammonium chloride; zinc in ethanol; water T=20 - 80°C; 2.16667 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; FINK, Brian; CHEN, Libing; GAVAI, Ashvinikumar; HE, Liqi; KIM, Soong-Hoon; NATION, Andrew; ZHAO, Yufen; ZHANG, Litai
Patent: WO2010/42699 A1, 2010 ;
Location in patent: Page/Page column 72-73 ;
WO 2010/042699 A1
反应条件
1: 86 percent / hydrogen, KOH / 5percent Pd/C / methanol / 1 h / 60004.8 - 75005.9 Torr View Scheme
参考文献
Aymes, Daniel J.; Paris, Michel R.
Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 3-4 p. 175 - 178
反应条件
N-ethyl-N,N-diisopropylamine; palladium diacetate; tris(4-methoxyphenyl)-phosphine in N,N-dimethyl-formamide
T=85°C; 72 h;
参考文献
WYETH
Patent: WO2008/150848 A1, 2008 ;
Location in patent: Page/Page column 140-141 ;
WO 2008/150848 A1
