1-乙烯基-6-氟-4-氧代-7-哌嗪-1-基-1,8-萘啶-3-羧酸合成路线 （共 6 条）
反应条件
sodium hydroxide in acetic acid
参考文献
Dainippon Pharmaceutical Co., Ltd.; Laboratoire Roger Bellon
Patent: US4352803 A1, 1982 ;
反应条件
sodium hydroxide
2 h; Heating;
参考文献
Matsumoto; Miyamoto; Minamida; Nishimura; Egawa
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 292 - 301
反应条件
1: 92.9 percent / K2CO3 / dimethylformamide / 3 h / 100 °C
2: 90.3 percent / SOCl2 / CHCl3 / 0.5 h / Heating
3: 80.6 percent / KOH / ethanol / 2 h / Heating
4: 82.4 percent / 10percent NaOH / 2 h / Heating
View Scheme
参考文献
Matsumoto; Miyamoto; Minamida; Nishimura; Egawa
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 292 - 301
反应条件
1: 80.6 percent / KOH / ethanol / 2 h / Heating
2: 82.4 percent / 10percent NaOH / 2 h / Heating
View Scheme
参考文献
Matsumoto; Miyamoto; Minamida; Nishimura; Egawa
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 292 - 301
反应条件
1: 90.3 percent / SOCl2 / CHCl3 / 0.5 h / Heating
2: 80.6 percent / KOH / ethanol / 2 h / Heating
3: 82.4 percent / 10percent NaOH / 2 h / Heating
View Scheme
参考文献
Matsumoto; Miyamoto; Minamida; Nishimura; Egawa
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 292 - 301
反应条件
formic acid in water
T=120 - 125°C; 17 h;
参考文献
Matsumoto; Miyamoto; Minamida; Nishimura; Egawa
Journal of Medicinal Chemistry, 1984 , vol. 27, # 3 p. 292 - 301
