2-氨基-5-溴-6-甲基吡嗪合成路线 （共 4 条）
反应条件
N-bromosuccinmide in water; dimethyl sulfoxide T=20°C; 5.25 h; Inert atmosphereCooling with ice;
参考文献
DOMAIN THERAPEUTICS; MAYER, Stanislas; SCHANN, Stephan
Patent: WO2013/174822 A1, 2013 ;
Location in patent: Page/Page column 86 ;
反应条件
pyridine; bromine in chloroform 0.5 h; Ambient temperaturein the dark;
参考文献
Sato, Nobuhiro
Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 143 - 147
反应条件
1: 64 percent / 1,2,3,4-tetrahydro-naphthalene / 1 h / 202 °C 2: bromine, pyridine / CHCl3 / 0.5 h / Ambient temperature; in the dark View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 17, p. 143 - 147
反应条件
in N,N-dimethyl-formamide
T=120°C; 15 h;
参考文献
NOVARTIS AG; FLOHR, Stefanie; MARKERT, Christian; NAMOTO, Kenji; PIRARD, Bernard
Patent: WO2013/111108 A1, 2013 ;
Location in patent: Page/Page column 45-46 ;
