2-(苄氧基)-6-羟基苯甲酸甲酯合成路线 （共 7 条）
反应条件
sodium hydrogencarbonate in N,N-dimethyl-formamide
参考文献
SmithKline Beecham Corporation
Patent: US6204294 B1, 2001 ;
US 6204294 B1
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran
T=25°C;
参考文献
Bass, R. J.; Banks, B. J.; Snarey, M.
Tetrahedron Letters, 1980 , vol. 21, p. 769 - 770
反应条件
potassium carbonate; sodium iodide in N,N-dimethyl-formamide
T=0 - 20°C; 4.5 h;
参考文献
Ohzeki, Tomoya; Mori, Kenji
Bioscience, biotechnology, and biochemistry, 2003 , vol. 67, # 10 p. 2240 - 2244
反应条件
1: 98 percent / hydrogen / palladium on carbon / ethyl acetate / 0.5 h
2: 48 percent / potassium carbonate; sodium iodide / dimethylformamide / 4.5 h / 0 - 20 °C
View Scheme
参考文献
Ohzeki, Tomoya; Mori, Kenji
Bioscience, biotechnology, and biochemistry, 2003 , vol. 67, # 10 p. 2240 - 2244
反应条件
1: 60 percent
2: 1.) NaH, 2.) tetrabutylammonium iodide / 1.) THF, 10 min, 2.) THF, reflux, 2 h
View Scheme
参考文献
Winn, Martin; De, Biswanath; Zydowsky, Thomas M.; Altenbach, Robert J.; Basha, Fatima Z.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 18 p. 2676 - 2688
反应条件
1: pyridine / 2 h / cooling
2: 1.55 g / potassium carbonate / tetrakis(triphenylphosphine)palladium(0) / benzene; ethanol / 14 h / Heating
View Scheme
参考文献
Ohzeki, Tomoya; Mori, Kenji
Bioscience, biotechnology, and biochemistry, 2003 , vol. 67, # 10 p. 2240 - 2244
反应条件
1: With sodium hydroxide in tetrahydrofuran; water
T=80°C; 24 h;
2: With hydrogenchloride in tetrahydrofuran; water
pH=1 - 2;
参考文献
Fan, Xing; Zhang, Feng-Hua; Al-Safi, Rasha I.; Zeng, Li-Fan; Shabaik, Yumna; Debnath, Bikash; Sanchez, Tino W.; Odde, Srinivas; Neamati, Nouri; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 16 p. 4935 - 4952
