反式-3-氨基环丁基甲酸合成路线 （共 13 条）
反应条件
1: 85 percent / H2 / PtO2 / methanol / 7 h 2: 88 percent / pyridine / 336 h 3: 1. NH4Br, NH3; 2. HCl / 1. 88 deg C, 16 h; 2. H2O, 88 deg C, 20 h, heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 47, # 9 p. 2440 - 2447
反应条件
1: 83 percent / 1. 150 deg C, 1 h, 4.0E3 Pa; 2. 165 deg C, 2.5 h; 3. 180 deg C, 2.5 h 2: 81 percent / H2SO4 / CHCl3 / 16 h / Heating 3: 85 percent / H2 / PtO2 / methanol / 7 h 4: 88 percent / pyridine / 336 h 5: 1. NH4Br, NH3; 2. HCl / 1. 88 deg C, 16 h; 2. H2O, 88 deg C, 20 h, heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 47, # 9 p. 2440 - 2447
反应条件
1: 81 percent / H2SO4 / CHCl3 / 16 h / Heating 2: 85 percent / H2 / PtO2 / methanol / 7 h 3: 88 percent / pyridine / 336 h 4: 1. NH4Br, NH3; 2. HCl / 1. 88 deg C, 16 h; 2. H2O, 88 deg C, 20 h, heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 47, # 9 p. 2440 - 2447
反应条件
1: 92 percent / KOH / aq. ethanol / 1.5 h / Heating 2: 83 percent / 1. 150 deg C, 1 h, 4.0E3 Pa; 2. 165 deg C, 2.5 h; 3. 180 deg C, 2.5 h 3: 81 percent / H2SO4 / CHCl3 / 16 h / Heating 4: 85 percent / H2 / PtO2 / methanol / 7 h 5: 88 percent / pyridine / 336 h 6: 1. NH4Br, NH3; 2. HCl / 1. 88 deg C, 16 h; 2. H2O, 88 deg C, 20 h, heating View Scheme
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 47, # 9 p. 2440 - 2447
反应条件
1: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 3 h / 750.08 Torr 2: hydrogenchloride; water / 1 h / Reflux View Scheme
参考文献
Synthetic Communications, , vol. 41, # 11 p. 1644 - 1649
反应条件
1: thionyl chloride / dichloromethane / 1 h / Reflux 2: 1 h / Reflux 3: sodium azide / N,N-dimethyl-formamide / 75 h / 100 °C 4: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 3 h / 750.08 Torr 5: hydrogenchloride; water / 1 h / Reflux View Scheme
参考文献
Synthetic Communications, , vol. 41, # 11 p. 1644 - 1649
反应条件
1: sulfuryl dichloride 2: pyridine / 18 h / Reflux 3: thionyl chloride / dichloromethane / 1 h / Reflux 4: 1 h / Reflux 5: sodium azide / N,N-dimethyl-formamide / 75 h / 100 °C 6: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 3 h / 750.08 Torr 7: hydrogenchloride; water / 1 h / Reflux View Scheme
参考文献
Synthetic Communications, , vol. 41, # 11 p. 1644 - 1649
反应条件
1: 1 h / Reflux 2: sodium azide / N,N-dimethyl-formamide / 75 h / 100 °C 3: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 3 h / 750.08 Torr 4: hydrogenchloride; water / 1 h / Reflux View Scheme
参考文献
Synthetic Communications, , vol. 41, # 11 p. 1644 - 1649
反应条件
1: pyridine / 18 h / Reflux 2: thionyl chloride / dichloromethane / 1 h / Reflux 3: 1 h / Reflux 4: sodium azide / N,N-dimethyl-formamide / 75 h / 100 °C 5: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 3 h / 750.08 Torr 6: hydrogenchloride; water / 1 h / Reflux View Scheme
参考文献
Synthetic Communications, , vol. 41, # 11 p. 1644 - 1649
反应条件
1: sodium azide / N,N-dimethyl-formamide / 75 h / 100 °C 2: hydrogenchloride; palladium 10 on activated carbon; hydrogen / methanol; water / 3 h / 750.08 Torr 3: hydrogenchloride; water / 1 h / Reflux View Scheme
参考文献
Synthetic Communications, , vol. 41, # 11 p. 1644 - 1649
