3-羟基氨基-1-甲基-5H-吡啶并(4,3-b)吲哚合成路线 （共 6 条）
反应条件
hydrazine hydrate; palladium on activated charcoal in tetrahydrofuran
T=-20°C; 1 h;
参考文献
Rajagopal, Sridharan; Brooks, Michael E.; Nguyen, Thach-Mien; Novak, Michael
Tetrahedron, 2003 , vol. 59, # 40 p. 8003 - 8010
反应条件
1: 40 percent / acetonitrile; H2O / 20 °C / pH 7.0
2: acetonitrile; H2O / 20 °C / pH 2.0
View Scheme
参考文献
Rajagopal, Sridharan; Brooks, Michael E.; Nguyen, Thach-Mien; Novak, Michael
Tetrahedron, 2003 , vol. 59, # 40 p. 8003 - 8010
反应条件
1: 40 percent / (CF3CO)2O; CF3COOH; H2O2 / Mo(CO)6 / CH2Cl2 / cooling
2: 96 percent / hydrazine monohydrate / Pd/C / tetrahydrofuran / 1 h / -20 °C
View Scheme
参考文献
Rajagopal, Sridharan; Brooks, Michael E.; Nguyen, Thach-Mien; Novak, Michael
Tetrahedron, 2003 , vol. 59, # 40 p. 8003 - 8010
反应条件
rat S9 mix; NADPH in phosphate buffer
Oxidation; hydroxylation; pH=7.4;
参考文献
Marczylo, Tim; Arimoto-Kobayashi, Sakae; Hayatsu, Hikoya
Mutagenesis, 2000 , vol. 15, # 3 p. 223 - 228
反应条件
in water; acetonitrile
T=20°C; pH=2.0;
参考文献
Rajagopal, Sridharan; Brooks, Michael E.; Nguyen, Thach-Mien; Novak, Michael
Tetrahedron, 2003 , vol. 59, # 40 p. 8003 - 8010
反应条件
1: 37 percent / triethylamine / tetrahydrofuran / 0.5 h / -20 - 0 °C
2: 91 percent / triethylamine / tetrahydrofuran / 1 h / 0 °C
3: acetonitrile; H2O / 20 °C / pH 7.0
View Scheme
参考文献
Rajagopal, Sridharan; Brooks, Michael E.; Nguyen, Thach-Mien; Novak, Michael
Tetrahedron, 2003 , vol. 59, # 40 p. 8003 - 8010
