反应条件
1: 1.) trifluoroacetic acid 2.) N-methylmorpholine, isobutyl-chloroformiate, NN-diisopropylethylamine / 1.) 30 min, RT, 2.) DMF, -20 deg C, 5 min, 3.) 1 h, room temp. 2: 1.) H2 2.) N,N-diisopropylethylamine / 1.) 10percent Pd/C / 1.) DMF, AcOH, H2O, RT, 2.) DMF, 3 h, RT 3: 1.) H2 2.) N,N-diisopropylethylamine / 1.) 10percent Pd/C / 1.) DMF, AcOH, H2O, RT, 2.) DMF, 3 h, RT 4: 46 percent / SO3-pyridene complex / pyridine; dimethylformamide / Ambient temperature View Scheme
参考文献
Mendre; Rodriguez; Laur; Aumelas; Martinez
Tetrahedron, 1988 , vol. 44, # 14 p. 4415 - 4430
