2-乙炔基-1,3-二甲基苯合成路线 （共 11 条）
反应条件
methanol; potassium carbonate
T=20°C; 2 h;
参考文献
Doherty, Simon; Knight, Julian G.; McGrady, John P.; Ferguson, Alexandra M.; Ward, Nicholas A. B.; Harrington, Ross W.; Clegg, William
Advanced Synthesis and Catalysis, 2010 , vol. 352, # 1 p. 201 - 211
反应条件
18-crown-6 ether; potassium tert-butylate
参考文献
Apeloig, Yitzhak; Franke, Wilfried; Rappoport, Zvi; Schwarz, Helmut; Stahl, Daniel
Journal of the American Chemical Society, 1981 , vol. 103, # 10 p. 2770 - 2780
反应条件
sodium amide in tetrahydrofuran; toluene
18 h; Heating;
参考文献
Knorr, Rudolf; Behringer, Claudia; Noeth, Heinrich; Schmidt, Martin; Lattke, Ernst; Raepple, Edith
Chemische Berichte, 1997 , vol. 130, # 5 p. 585 - 592
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 60 °C / Inert atmosphere
2: methanol; potassium carbonate / dichloromethane / 2 h / 20 °C
View Scheme
参考文献
Jahier, Claire; Zatolochnaya, Olga V.; Zvyagintsev, Nickolay V.; Ananikov, Valentine P.; Gevorgyan, Vladimir
Organic Letters, 2012 , vol. 14, # 11 p. 2846 - 2849
反应条件
1: 1.) Br2, 2.) KOBu-t
2: 93.8 percent / KOBu-t, 18-crown-6 ether
View Scheme
参考文献
Apeloig, Yitzhak; Franke, Wilfried; Rappoport, Zvi; Schwarz, Helmut; Stahl, Daniel
Journal of the American Chemical Society, 1981 , vol. 103, # 10 p. 2770 - 2780
反应条件
magnesium
1.) THF, -78 deg C, 30 min, 2.) reflux, 60 h; Yield given. Multistep reaction;
参考文献
Eisch, John J.; Shafii, Babak; Odom, Jerome D.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1990 , vol. 112, # 5 p. 1847 - 1853
反应条件
1: copper(I)iodide; dichlorobis(triphenylphosphine) palladium (II); PPh3 / various solvent(s) / 2 h / Heating
2: 1.94 g / Bu4NF / tetrahydrofuran; H2O / 1.5 h / 20 °C
View Scheme
参考文献
Panda, Jagannath; Virkler, Peter R.; Detty, Michael R.
Journal of Organic Chemistry, 2003 , vol. 68, # 5 p. 1804 - 1809
反应条件
1: thionyl chloride
2: diethyl ether
3: 1.) PCl5, 2.) potassium tert-butoxide / 2.) DMSO
View Scheme
参考文献
Yates, Keith; Mandrapilias, George
Journal of Organic Chemistry, 1980 , vol. 45, # 19 p. 3892 - 3902
反应条件
1: 1) diazotation
2: thionyl chloride
3: diethyl ether
4: 1.) PCl5, 2.) potassium tert-butoxide / 2.) DMSO
View Scheme
参考文献
Yates, Keith; Mandrapilias, George
Journal of Organic Chemistry, 1980 , vol. 45, # 19 p. 3892 - 3902
反应条件
1: diethyl ether
2: 1.) PCl5, 2.) potassium tert-butoxide / 2.) DMSO
View Scheme
参考文献
Yates, Keith; Mandrapilias, George
Journal of Organic Chemistry, 1980 , vol. 45, # 19 p. 3892 - 3902
