(±)-Alpha-氨基-3-羟基-5-甲基异恶唑-4-丙酸合成路线 （共 9 条）
反应条件
hydrogen bromide; triethylamine in ethanol; water 0.333333 h; Heating;
参考文献
Hansen; Krogsgaard-Larsen
Journal of the Chemical Society. Perkin transactions 1, 1980 , vol. 8, p. 1826 - 1833
反应条件
trifluoroacetic acid 16 h; Heating;
参考文献
Begtrup; Slok
Synthesis, 1993 , # 9 p. 861 - 863
反应条件
1: 76 percent / NaH / dimethylformamide / 12 h / 20 °C 2: 60 percent / 1 M aq. CF3CO2H / 16 h / Heating View Scheme
参考文献
Synthesis, , # 9 p. 861 - 863
反应条件
1: 67 percent / N-bromosuccinimide, PPh3 / CH2Cl2 / 0.5 h / Ambient temperature 2: 76 percent / KOH, tetrabutylammonium iodide / CH2Cl2 / 16 h / Ambient temperature 3: 65 percent / 45percent HBr / 0.5 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 18 p. 2151 - 2152
反应条件
1: 76 percent / KOH, tetrabutylammonium iodide / CH2Cl2 / 16 h / Ambient temperature 2: 65 percent / 45percent HBr / 0.5 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 18 p. 2151 - 2152
反应条件
1: 89 percent / KOH / H2O / 12 h / Heating 2: 67 percent / N-bromosuccinimide, PPh3 / CH2Cl2 / 0.5 h / Ambient temperature 3: 76 percent / KOH, tetrabutylammonium iodide / CH2Cl2 / 16 h / Ambient temperature 4: 65 percent / 45percent HBr / 0.5 h / Heating View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 18 p. 2151 - 2152
反应条件
1: 45 percent / sodium ethoxide / ethanol / 4.5 h / Heating 2: 86 percent / HBr, triethylamine / H2O; ethanol / 0.33 h / Heating View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 8, p. 1826 - 1833
反应条件
1: 75 percent / LiAlH4 / diethyl ether / 6 h / Ambient temperature 2: 80 percent / thionyl chloride / 0.42 h / Heating 3: 45 percent / sodium ethoxide / ethanol / 4.5 h / Heating 4: 86 percent / HBr, triethylamine / H2O; ethanol / 0.33 h / Heating View Scheme
参考文献
Journal of the Chemical Society. Perkin transactions 1, , vol. 8, p. 1826 - 1833
参考文献
Begtrup; Slok
Synthesis, 1993 , # 9 p. 861 - 863
