3-氯-4-(1-甲基乙氧基)-g-氧代-苯丁酸合成路线 （共 4 条）
反应条件
1: 79 percent / AlCl3 / nitrobenzene / 1) 20 deg C, 3 h, 2) 45 deg C, 1 h
2: 50percent hydrobromic acid / H2O / 16 h / Heating
3: p-toluenesulphonic acid / 5 h / Heating
4: 1) Na / 1) methanol, 10 min, 2) DMSO, 100 deg C, 8 h
View Scheme
参考文献
Kuchar, Miroslav; Brunova, Bohumila; Grimova, Jaroslava; Rejholec, Vaclav; Cepelak, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 11 p. 2617 - 2625
反应条件
1: 50percent hydrobromic acid / H2O / 16 h / Heating
2: p-toluenesulphonic acid / 5 h / Heating
3: 1) Na / 1) methanol, 10 min, 2) DMSO, 100 deg C, 8 h
View Scheme
参考文献
Kuchar, Miroslav; Brunova, Bohumila; Grimova, Jaroslava; Rejholec, Vaclav; Cepelak, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 11 p. 2617 - 2625
反应条件
1: p-toluenesulphonic acid / 5 h / Heating
2: 1) Na / 1) methanol, 10 min, 2) DMSO, 100 deg C, 8 h
View Scheme
参考文献
Kuchar, Miroslav; Brunova, Bohumila; Grimova, Jaroslava; Rejholec, Vaclav; Cepelak, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 11 p. 2617 - 2625
反应条件
sodium
1) methanol, 10 min, 2) DMSO, 100 deg C, 8 h; Yield given. Multistep reaction;
参考文献
Kuchar, Miroslav; Brunova, Bohumila; Grimova, Jaroslava; Rejholec, Vaclav; Cepelak, Vaclav
Collection of Czechoslovak Chemical Communications, 1986 , vol. 51, # 11 p. 2617 - 2625
