4-[3-(4-羟基苯基)-2,3-二甲基丁烷-2-基]苯酚合成路线 （共 6 条）
反应条件
boron tribromide in dichloromethane
1.) -60 deg C, 0.5 h, 2.) RT, 4 h;
参考文献
Hartmann, Rolf W.; Kranzfelder, Gerhard; Angerer, Erwin, v.; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 841 - 848
反应条件
boron tribromide in chloroform
10 h; Yield given. Yields of byproduct given;
参考文献
Zimmerman, Howard E.; Kamath, Ajit P.
Journal of the American Chemical Society, 1988 , vol. 110, # 3 p. 900 - 911
反应条件
1: 60 percent / TiCl3, LiAlH4 / 1,2-dimethoxy-ethane / 16 h / Heating
2: 1.) BBr3, 2.) 2N NaOH / 1.) CH2Cl2, RT, 4 h, 2.) CH2Cl2, MeOH
View Scheme
参考文献
Hartmann; Schwarz; Heindl; Schonenberger
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1295 - 1301
反应条件
1: 1.) Mg / 1.) ether, reflux, 0.5 h, 2.) ether, reflux, 2 h
2: 60 percent / TiCl3, LiAlH4 / 1,2-dimethoxy-ethane / 16 h / Heating
3: 1.) BBr3, 2.) 2N NaOH / 1.) CH2Cl2, RT, 4 h, 2.) CH2Cl2, MeOH
View Scheme
参考文献
Hartmann; Schwarz; Heindl; Schonenberger
Journal of Medicinal Chemistry, 1985 , vol. 28, # 9 p. 1295 - 1301
反应条件
1: 1.) magnesium / 1.) ether, reflux, 0.5 h, 2.) ether, reflux, 2 h
2: 60 percent / TiCl3, LiAlH4 / 1,2-dimethoxy-ethane / 16 h / Heating
3: 89 percent / BBr3 / CH2Cl2 / 1.) -60 deg C, 0.5 h, 2.) RT, 4 h
View Scheme
参考文献
Hartmann, Rolf W.; Kranzfelder, Gerhard; Angerer, Erwin, v.; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 841 - 848
反应条件
in tetrahydrofuran
-78 deg C to 66 deg C in 1 h; 66 deg C, 3 h;
参考文献
Kauffmann, Thomas; Jordan, Jan; Voss, Karl-Uwe; Wilde, Heinz-Wilhelm
Chemische Berichte, 1993 , vol. 126, # 9 p. 2083 - 2092
