4-氟-3-甲氧基苯甲酸甲酯合成路线 （共 11 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
Chen, Yi; Dermatakis, Apostolos; Liu, Jin-Jun; Luk, Kin-Chun; Michoud, Christophe; Rossman, Pamela Loreen
Patent: US2004/204427 A1, 2004 ;
Location in patent: Page/Page column 42 ;
US 20040204427 A1
反应条件
sulfuric acid 16 h; Heating;
参考文献
Harris, Craig S.; Kettle, Jason G.; Williams, Emma J.
Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7381 - 7384
反应条件
tetrafluoroboric acid; sodium nitrite 1.) water, -5 deg C, 2.) decomposition by dry distillation under reduced pressure; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 23, # 8 p. 841 - 848
反应条件
water; sodium hydroxide in methanol T=20°C; 4 h;
参考文献
BIOENERGENIX; MCCALL, John; KELLY, Robert, C.; ROMERO, Donna, L.
Patent: WO2014/66795 A1, 2014 ;
Location in patent: Paragraph 0175 ;
反应条件
1: 62 percent / HNO3; H2SO4 / 0.5 h / 0 - 10 °C 2: 89 percent / hydrogen / Pd/C / ethanol / 6 h / 20 °C 3: 68 percent / acetic acid / 135 °C 4: 95 percent / SOCl2 / 16 h / Heating View Scheme
参考文献
Harris, Craig S.; Kettle, Jason G.; Williams, Emma J.
Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7381 - 7384
反应条件
nitric acid; palladium in ethanol
参考文献
Zeneca Limited
Patent: US5580870 A1, 1996 ;
US 5580870 A
参考文献
ZENECA LIMITED
Patent: EP635498 A1, 1995 ;
EP 0635498 A1
反应条件
1: 62 percent / HNO3; H2SO4 / 0.5 h / 0 - 10 °C 2: 89 percent / hydrogen / Pd/C / ethanol / 6 h / 20 °C View Scheme
参考文献
Harris, Craig S.; Kettle, Jason G.; Williams, Emma J.
Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7381 - 7384
反应条件
nitric acid; palladium in ethanol
参考文献
Zeneca Limited
Patent: US5580870 A1, 1996 ;
US 5580870 A
反应条件
sulfuric acid; nitric acid T=0 - 10°C; 0.5 h;
参考文献
Harris, Craig S.; Kettle, Jason G.; Williams, Emma J.
Tetrahedron Letters, 2005 , vol. 46, # 43 p. 7381 - 7384
