Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂合成路线 （共 41 条）
反应条件
in pyridine T=50°C; 8 h;
参考文献
Pharmazie, , vol. 41, # 8 p. 596 - 596
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 23, # 34 p. 3507 - 3510
反应条件
deprotection and reacylation; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 30, # 8 p. 915 - 918
反应条件
1: NaH 2: LiAlH4 4: pyridine 5: silica gel, boric acid / petroleum ether 6: benzene / 60 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 21 p. 3463 - 3466
反应条件
1: 96 percent / 2,6-di-t-butyl-4-methylpyridine / CH2Cl2 2: 1.) CsOAc ; 2.) LiAlH4 / 1.) DMF,DMSO ; 2.) Et2O 3: 1.) POCl3,Et3N ; 2.) pyridine / 1.) CHCl3 ; 2.) rt 4: H2 / Pd(OH)2/C / methanol; H2O / 24 h 5: DMAP / CHCl3 View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 35 p. 4393 - 4396
反应条件
1: 1.) CsOAc ; 2.) LiAlH4 / 1.) DMF,DMSO ; 2.) Et2O 2: 1.) POCl3,Et3N ; 2.) pyridine / 1.) CHCl3 ; 2.) rt 3: H2 / Pd(OH)2/C / methanol; H2O / 24 h 4: DMAP / CHCl3 View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 35 p. 4393 - 4396
反应条件
2: pyridine 3: silica gel, boric acid / petroleum ether 4: benzene / 60 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 21 p. 3463 - 3466
反应条件
1: sodium borohydride / tetrahydrofuran; H2O / 0.5 h 2: 1.) triethylamine, phosphoroxychloride, 2.) triethylamine, 3.) potassium carbonate 3: hydrogen, 1 N HCl / 5percent Pd/C / methanol; tetrahydrofuran / 760 Torr / Ambient temperature 4: 84 percent / DMAP / CHCl3 / 16 h / 30 °C View Scheme
参考文献
Chemistry and Physics of Lipids, , vol. 76, # 2 p. 211 - 224
参考文献
Tetrahedron Letters, , vol. 23, # 34 p. 3507 - 3510
反应条件
1: 1.24 g / KH, dibenzo-18-crown-6 / tetrahydrofuran / 7 h / Ambient temperature 2: 624 mg / 9 percent HCl-MeOH / 2 h / Ambient temperature 3: Et3N / 1.) Et2O, RT, 8 h, 2.) Et2O, water, reflux, 2 h 4: 2.) Ag2CO3 / 1.) CHCl3, iso-PrOH-DMF, 50 deg C, 2 h, 2.) reflux, 1 h 5: 81 mg / hydrogen / 10 percent Pd-C / methanol / 8 h / Ambient temperature 6: 59 mg / pyridine / 10 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 5 p. 1166 - 1169
