Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂合成路线 （共 41 条）
反应条件
N,N,N',N'-tetramethylguanidinium-cis-4-nitro-benzaldoximate in tetrahydrofuran T=20°C; 2 h; Yield given;
参考文献
Synthesis, , # 5 p. 399 - 402
反应条件
1: 1 N hydrochloric acid / 5 h / 70 °C 2: sodium borohydride / tetrahydrofuran; H2O / 0.5 h 3: 1.) triethylamine, phosphoroxychloride, 2.) triethylamine, 3.) potassium carbonate 4: hydrogen, 1 N HCl / 5percent Pd/C / methanol; tetrahydrofuran / 760 Torr / Ambient temperature 5: 84 percent / DMAP / CHCl3 / 16 h / 30 °C View Scheme
参考文献
Chemistry and Physics of Lipids, , vol. 76, # 2 p. 211 - 224
反应条件
2: H2 / Pd-C / ethanol; tetrahydrofuran / 48 h / 2942.03 Torr / Ambient temperature 3: NEt3 View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 5 p. 699 - 702
反应条件
1: 87 percent / PPh3/H3COCON=NCOOCH3 / tetrahydrofuran / Ambient temperature 2: p-TsOH 4: H2 / Pd-C / ethanol; tetrahydrofuran / 48 h / 2942.03 Torr / Ambient temperature 5: NEt3 View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 5 p. 699 - 702
反应条件
1: H2 / Pd-C / ethanol; tetrahydrofuran / 48 h / 2942.03 Torr / Ambient temperature 2: NEt3 View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 5 p. 699 - 702
反应条件
1: p-TsOH 3: H2 / Pd-C / ethanol; tetrahydrofuran / 48 h / 2942.03 Torr / Ambient temperature 4: NEt3 View Scheme
参考文献
Tetrahedron Letters, , vol. 31, # 5 p. 699 - 702
反应条件
1: N,N-diisopropylethylamine / tetrahydrofuran / 0.25 h / -20 °C 2: Br2 / 0.02 h / -20 °C 3: 1.) H2O / 1.) 15 min, 2.) CH3CN, i-PrOH, CHCl3, 12 h 4: DMAP / CHCl3 / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 60, # 23 p. 7706 - 7708
反应条件
1: silica gel, boric acid / petroleum ether 2: benzene / 60 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 21 p. 3463 - 3466
反应条件
1: 624 mg / 9 percent HCl-MeOH / 2 h / Ambient temperature 2: Et3N / 1.) Et2O, RT, 8 h, 2.) Et2O, water, reflux, 2 h 3: 2.) Ag2CO3 / 1.) CHCl3, iso-PrOH-DMF, 50 deg C, 2 h, 2.) reflux, 1 h 4: 81 mg / hydrogen / 10 percent Pd-C / methanol / 8 h / Ambient temperature 5: 59 mg / pyridine / 10 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 5 p. 1166 - 1169
反应条件
1: 2.) Ag2CO3 / 1.) CHCl3, iso-PrOH-DMF, 50 deg C, 2 h, 2.) reflux, 1 h 2: 81 mg / hydrogen / 10 percent Pd-C / methanol / 8 h / Ambient temperature 3: 59 mg / pyridine / 10 h / Ambient temperature View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 40, # 5 p. 1166 - 1169
