Β-乙酰基-Γ-O-十六烷基-L-Α-卵磷脂合成路线 （共 41 条）
反应条件
1: KH (22percent) / benzene / Ambient temperature 2: 92 percent / p-toluenesulfonic acid monohydrate / methanol / Heating 3: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h 4: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 5: 95 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr 6: 93 percent / pyridine / 2 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
1: Pb(OAc)4 / benzene / 2 h / Ambient temperature 2: NaBH4 / methanol; tetrahydrofuran / Ambient temperature 3: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h 4: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 5: 95 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr 6: 93 percent / pyridine / 2 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
1: 91 percent / HCl (2N) / tetrahydrofuran / 3 h / Ambient temperature 2: Pb(OAc)4 / benzene / 2 h / Ambient temperature 3: NaBH4 / methanol; tetrahydrofuran / Ambient temperature 4: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h 5: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 6: 95 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr 7: 93 percent / pyridine / 2 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
1: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 2: 95 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr 3: 93 percent / pyridine / 2 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
1: 78 percent / HCl (2N) / tetrahydrofuran / Ambient temperature 2: 92 percent / 4,4-dimethylaminopyridine / pyridine / 3 h / 100 °C 3: KH (22percent) / benzene / Ambient temperature 4: 92 percent / p-toluenesulfonic acid monohydrate / methanol / Heating 5: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h 6: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 7: 95 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr 8: 93 percent / pyridine / 2 h / 70 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
1: pyridine 2: silica gel, boric acid / petroleum ether 3: benzene / 60 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 34, # 21 p. 3463 - 3466
反应条件
1: POCl3, Et3N / CHCl3 / 0.5 h / 0 °C 2: pyridine / CHCl3 / 14 h / Ambient temperature View Scheme
参考文献
Chemistry Letters, , # 8 p. 1417 - 1420
反应条件
4-(N,N-dimethlyamino)pyridine in acetonitrile; benzene T=70°C; 0.25 h; Title compound not separated from byproducts;
参考文献
Russian Journal of Bioorganic Chemistry, , vol. 19, # 11 p. 667 - 674
Bioorganicheskaya Khimiya, , vol. 19, # 11 p. 1111 - 1121
反应条件
4-(N,N-dimethlyamino)pyridine in chloroform 3 h; Ambient temperature; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 60, # 23 p. 7706 - 7708
反应条件
1: 1-Methylimidazole / acetonitrile; tetrahydrofuran / 0.75 h 2: N,N,N',N'-tetramethylguanidinium syn-4-nitrobenzaldoximate / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
Synthesis, , # 5 p. 399 - 402
