2,3,5-三甲基吡啶 1-氧化物合成路线 （共 15 条）
反应条件
1: HNO3 / Heating
3: 110 °C
4: aq. NaOH / methanol / Heating
5: 90 percent / SOCl2 / CH2Cl2 / 0.5 h / Heating
6: 84 percent / aq. NaOH / methanol / Heating
View Scheme
参考文献
Kuehler, Thomas C.; Swanson, Marianne; Shcherbuchin, Vladimir; Larsson, Hakan; Mellgard, Bjoern; Sjoestroem, Jan-Eric
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1777 - 1788
反应条件
sodium hydroxide; nitric acid in methanol; conc. H2 SO4; toluene
参考文献
Aktiebolaget Hassle
Patent: US4544750 A1, 1985 ;
反应条件
1: HNO3 / Heating
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
反应条件
bromine; potassium carbonate in tetrachloromethane
2 h; Heating;
参考文献
CONFORMA THERAPEUTICS CORPORATION
Patent: WO2005/28434 A2, 2005 ;
Location in patent: Page/Page column 243-244; 294; 338; 348-349 ;
反应条件
1: HNO3 / Heating
3: 110 °C
View Scheme
参考文献
Kohl; Sturm; Senn-Bilfinger; Simon; Kruger; Schaefer; Rainer; Figala; Klemm
Journal of Medicinal Chemistry, 1992 , vol. 35, # 6 p. 1049 - 1057
