1-(3-三氟甲基苯基)-1,4-高哌嗪合成路线 （共 3 条）
反应条件
LiAlH4 in tetrahydrofuran
参考文献
BOEHRINGER INGELHEIM ITALIA S.p.A.
Patent: EP526434 A1, 1993 ;
反应条件
1: caesium carbonate; copper(l) iodide; (α-isobutyryl)cyclohexanone / N,N-dimethyl-formamide / 70 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Foley, Timothy L.; Rai, Ganesha; Yasgar, Adam; Daniel, Thomas; Baker, Heather L.; Attene-Ramos, Matias; Kosa, Nicolas M.; Leister, William; Burkart, Michael D.; Jadhav, Ajit; Simeonov, Anton; Maloney, David J.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 1063 - 1078
反应条件
1: caesium carbonate; copper(l) iodide; (α-isobutyryl)cyclohexanone / N,N-dimethyl-formamide / 70 °C
2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C
View Scheme
参考文献
Foley, Timothy L.; Rai, Ganesha; Yasgar, Adam; Daniel, Thomas; Baker, Heather L.; Attene-Ramos, Matias; Kosa, Nicolas M.; Leister, William; Burkart, Michael D.; Jadhav, Ajit; Simeonov, Anton; Maloney, David J.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 1063 - 1078
