4-氯-1H-吡咯并[2,3-B]吡啶 7-氧化物合成路线 （共 3 条）
反应条件
methanesulfonyl chloride in N,N-dimethyl-formamide T=80°C; 3 h;
参考文献
L'Heureux, Alexandre; Thibault, Carl; Ruel, Rejean
Tetrahedron Letters, 2004 , vol. 45, # 11 p. 2317 - 2319
反应条件
3-chloro-benzenecarboperoxoic acid in diethyl ether
2 h; Ambient temperature;
参考文献
Schneller, Stewart W.; Luo, Jiann-Kuan
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4045 - 4048
反应条件
1.1: Cl3CCOCl; (Me3Si)2NH / tetrahydrofuran / 1 h
2.1: 62 percent / NaH / tetrahydrofuran / 1 h
3.1: 88 percent / K2CO3 / dimethylsulfoxide / 2 h / 100 °C
4.1: 92 percent / H2 / Pd/C / ethanol / 24 h / 20 °C
5.1: TFA / CH2Cl2 / 2 h / 20 °C
5.2: 79 percent / AcONa / ethanol / 1 h
View Scheme
参考文献
Figueroa-Perez, Santiago; Bennabi, Samir; Schirok, Hartmut; Thutewohl, Michael
Tetrahedron Letters, 2006 , vol. 47, # 13 p. 2069 - 2072
