4-硝基-1H-吡咯并[2,3-B]吡啶-7-氧化物合成路线 （共 13 条）
反应条件
nitric acid; trifluoroacetic acid in water T=20°C;
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/108397 A1, 2005 ;
Location in patent: Page/Page column 27-28 ;
反应条件
nitric acid; trifluoroacetic acid T=0°C;
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 10 p. 1258 - 1261
反应条件
sulfuric acid; nitric acid T=70 - 75°C; 1.5 h;
参考文献
Schneller, Stewart W.; Luo, Jiann-Kuan
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4045 - 4048
反应条件
1: 60 percent / m-chloroperbenzoic acid / CH2Cl2 / 6 h / Ambient temperature 2: 60 percent / HNO3, CF3CO2H / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 25, # 10 p. 1258 - 1261
反应条件
1: With methanesulfonyl chloride in N,N-dimethyl-formamide T=65°C; 2 h; 2: With sodium hydroxide in water; N,N-dimethyl-formamide T=0°C; pH=~ 6.5;
参考文献
ASTELLAS PHARMA INC.
Patent: WO2007/7919 A2, 2007 ;
Location in patent: Page/Page column 43-44 ;
WO 2007/007919 A2
反应条件
phosphorus trichoride in ethyl acetate Heating;
参考文献
Antonini; Claudi; Cristalli; Franchetti; Grifantini; Martelli
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1258 - 1261
反应条件
1: With iron; acetic acid 2 h; Heating / reflux; 2: With sodium hydroxide in water
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/39796 A1, 2004 ;
Location in patent: Page/Page column 65 ;
WO 2004/039796 A1
反应条件
1: 80 percent / PCl3 / ethyl acetate / Heating
2: 84 percent / H2, CF3CO2H / Pd/C / 5 h / 2844.3 Torr
View Scheme
参考文献
Antonini; Claudi; Cristalli; Franchetti; Grifantini; Martelli
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1258 - 1261
反应条件
1: Cl3CCOCl; (Me3Si)2NH / tetrahydrofuran / 1 h
2: 65 percent / NaH / tetrahydrofuran / 1 h
View Scheme
参考文献
Figueroa-Perez, Santiago; Bennabi, Samir; Schirok, Hartmut; Thutewohl, Michael
Tetrahedron Letters, 2006 , vol. 47, # 13 p. 2069 - 2072
反应条件
bromine in dichloromethane
T=0 - 20°C; 2 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/108397 A1, 2005 ;
Location in patent: Page/Page column 43-44 ;
