3-硝基-1H-吡咯并[2,3-B]吡啶-7-氧化物合成路线 （共 7 条）
反应条件
1: With methanesulfonyl chloride in N,N-dimethyl-formamide T=65°C; 2 h; 2: With sodium hydroxide in water; N,N-dimethyl-formamide T=0°C; pH=~ 6.5;
参考文献
ASTELLAS PHARMA INC.
Patent: WO2007/7919 A2, 2007 ;
Location in patent: Page/Page column 43-44 ;
WO 2007/007919 A2
反应条件
nitric acid; trifluoroacetic acid
T=0°C;
参考文献
Antonini; Claudi; Cristalli; Franchetti; Grifantini; Martelli
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1258 - 1261
反应条件
sulfuric acid; nitric acid
T=55 - 60°C; 2 h;
参考文献
Schneller, Stewart W.; Luo, Jiann-Kuan
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4045 - 4048
反应条件
sulfolane; nitronium tetrafluoroborate
2 h; Ambient temperature;
参考文献
Schneller, Stewart W.; Luo, Jiann-Kuan
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4045 - 4048
反应条件
1: 60 percent / m-chloroperbenzoic acid / CH2Cl2 / 6 h / Ambient temperature
2: 12 percent / HNO3, CF3CO2H / 0 °C
View Scheme
参考文献
Antonini; Claudi; Cristalli; Franchetti; Grifantini; Martelli
Journal of Medicinal Chemistry, 1982 , vol. 25, # 10 p. 1258 - 1261
反应条件
sulfuric acid; nitric acid
2 h; Ambient temperature;
参考文献
Schneller, Stewart W.; Luo, Jiann-Kuan
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4045 - 4048
反应条件
1: 61.6 percent / m-chloroperoxybenzoic acid / diethyl ether / 2 h / Ambient temperature
2: 21 percent / aq.HNO3, H2SO4 / 2 h / 55 - 60 °C
View Scheme
参考文献
Schneller, Stewart W.; Luo, Jiann-Kuan
Journal of Organic Chemistry, 1980 , vol. 45, # 20 p. 4045 - 4048
