6-(3-吡啶)-呋喃并[2,3-d]嘧啶-4-胺合成路线 （共 5 条）
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide); water
T=80°C;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/61516 A1, 2005 ;
Location in patent: Page/Page column 32; 34-35 ;
WO 2005/061516 A1
反应条件
1: With acetic acid
T=20°C; 1 h;
2: With ammonia in tetrahydrofuran; ethanol
T=0 - 20°C; 3.5 h;
3: With sodium ethanolate in tetrahydrofuran; ethanol
T=20°C; 2 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/61516 A1, 2005 ;
Location in patent: Page/Page column 30-31 ;
WO 2005/061516 A1
反应条件
1: NaOEt
2: piperidine / ethanol / Heating
3: NH3 / ethanol; tetrahydrofuran
4: NaOEt / ethanol; tetrahydrofuran
View Scheme
参考文献
Maeda, Yutaka; Nakano, Masato; Sato, Hideyuki; Miyazaki, Yasushi; Schweiker, Stephanie L.; Smith, Jeffery L.; Truesdale, Anne T.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3907 - 3911
反应条件
1: piperidine / ethanol / Heating
2: NH3 / ethanol; tetrahydrofuran
3: NaOEt / ethanol; tetrahydrofuran
View Scheme
参考文献
Maeda, Yutaka; Nakano, Masato; Sato, Hideyuki; Miyazaki, Yasushi; Schweiker, Stephanie L.; Smith, Jeffery L.; Truesdale, Anne T.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3907 - 3911
反应条件
1: NH3 / ethanol; tetrahydrofuran
2: NaOEt / ethanol; tetrahydrofuran
View Scheme
参考文献
Maeda, Yutaka; Nakano, Masato; Sato, Hideyuki; Miyazaki, Yasushi; Schweiker, Stephanie L.; Smith, Jeffery L.; Truesdale, Anne T.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 3907 - 3911
