Γ-O-十八烷基-L-Α-溶血卵磷脂合成路线 （共 45 条）
反应条件
hydrogen; Trimethylene glycol in methanol; water 1 h; Ambient temperature;
参考文献
Hirth; Barner
Helvetica Chimica Acta, 1982 , vol. 65, # 3 p. 1059 - 1084
反应条件
Tris-HCl buffer in chloroform T=35°C; 3 h; viper venom;
参考文献
Chupin, V. V.; Ostanenko, O. V.; Klykov, V. N.; Anikin, M. V.; Serebrennikova, G. A.
Russian Journal of Bioorganic Chemistry, 1993 , vol. 19, # 11 p. 667 - 674
Bioorganicheskaya Khimiya, 1993 , vol. 19, # 11 p. 1111 - 1121
反应条件
palladium in acetic acid
反应条件
1.1: POCl3; Et3N / CH2Cl2 / 0.5 h 1.2: pyridine / CH2Cl2 / 20 °C 2.1: 180 mg / H2 / Pd/C / ethyl acetate; methanol / 2.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7305 - 7314
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in dichloromethane; water 2 h;
参考文献
Pedersen, Palle J.; Christensen, Mikkel S.; Ruysschaert, Tristan; Linderoth, Lars; Andresen, Thomas L.; Melander, Fredrik; Mouritsen, Ole G.; Madsen, Robert; Clausen, Mads H.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 10 p. 3408 - 3415
反应条件
hydrogen; palladium on activated charcoal in tetrahydrofuran; ethanol P=2942.03 Torr; 48 h; Ambient temperature;
参考文献
Tetrahedron Letters, , vol. 31, # 5 p. 699 - 702
反应条件
1.1: POCl3; Et3N / CH2Cl2 / 0.5 h 1.2: pyridine / CH2Cl2 / 20 °C 2.1: 180 mg / H2 / Pd/C / ethyl acetate; methanol / 2.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7305 - 7314
反应条件
1.1: dimethylformamide; dimethylsulfoxide / 60 °C 2.1: 1.18 g / LiAlH4 / diethyl ether / 3.5 h / 0 - 20 °C 3.1: POCl3; Et3N / CH2Cl2 / 0.5 h 3.2: pyridine / CH2Cl2 / 20 °C 4.1: 180 mg / H2 / Pd/C / ethyl acetate; methanol / 2.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7305 - 7314
反应条件
1.1: 91 percent / BF3*OEt2 / CH2Cl2 2.1: 96 percent / CF3SO3H / dioxane / 0.67 h 3.1: dimethylformamide; dimethylsulfoxide / 60 °C 4.1: 1.18 g / LiAlH4 / diethyl ether / 3.5 h / 0 - 20 °C 5.1: POCl3; Et3N / CH2Cl2 / 0.5 h 5.2: pyridine / CH2Cl2 / 20 °C 6.1: 180 mg / H2 / Pd/C / ethyl acetate; methanol / 2.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7305 - 7314
反应条件
1.1: 96 percent / CF3SO3H / dioxane / 0.67 h 2.1: dimethylformamide; dimethylsulfoxide / 60 °C 3.1: 1.18 g / LiAlH4 / diethyl ether / 3.5 h / 0 - 20 °C 4.1: POCl3; Et3N / CH2Cl2 / 0.5 h 4.2: pyridine / CH2Cl2 / 20 °C 5.1: 180 mg / H2 / Pd/C / ethyl acetate; methanol / 2.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 23 p. 7305 - 7314
