1: 81 percent / pyridine / Ambient temperature 2: 99 percent / pyridine / CHCl3 / Ambient temperature 3: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 4: t-BuOK / tetrahydrofuran / Ambient temperature 5: dimethylformamide / 80 °C 6: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 7: 68.7 percent / pyridine / 72 h / Ambient temperature 8: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 9: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 10: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 11: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: 87 percent / NaH / dimethylformamide; petroleum ether / 3 h / 50 °C 2: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 3: 81 percent / pyridine / Ambient temperature 4: 99 percent / pyridine / CHCl3 / Ambient temperature 5: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 6: t-BuOK / tetrahydrofuran / Ambient temperature 7: dimethylformamide / 80 °C 8: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 9: 68.7 percent / pyridine / 72 h / Ambient temperature 10: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 11: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 12: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 13: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: 99 percent / pyridine / CHCl3 / Ambient temperature 2: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 3: t-BuOK / tetrahydrofuran / Ambient temperature 4: dimethylformamide / 80 °C 5: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 6: 68.7 percent / pyridine / 72 h / Ambient temperature 7: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 8: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 9: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 10: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: dimethylformamide / 80 °C 2: pyridine / CHCl3 / Ambient temperature 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 5: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 6: 81 percent / pyridine / Ambient temperature 7: 99 percent / pyridine / CHCl3 / Ambient temperature 8: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 9: t-BuOK / tetrahydrofuran / Ambient temperature 10: dimethylformamide / 80 °C 11: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 12: 68.7 percent / pyridine / 72 h / Ambient temperature 13: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 14: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 15: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 16: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: pyridine / CHCl3 / Ambient temperature 2: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 3: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 4: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 5: 81 percent / pyridine / Ambient temperature 6: 99 percent / pyridine / CHCl3 / Ambient temperature 7: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 8: t-BuOK / tetrahydrofuran / Ambient temperature 9: dimethylformamide / 80 °C 10: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 11: 68.7 percent / pyridine / 72 h / Ambient temperature 12: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 13: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 14: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 15: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 2: 81 percent / pyridine / Ambient temperature 3: 99 percent / pyridine / CHCl3 / Ambient temperature 4: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 5: t-BuOK / tetrahydrofuran / Ambient temperature 6: dimethylformamide / 80 °C 7: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 8: 68.7 percent / pyridine / 72 h / Ambient temperature 9: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 10: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 11: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 12: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 2: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 3: 81 percent / pyridine / Ambient temperature 4: 99 percent / pyridine / CHCl3 / Ambient temperature 5: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 6: t-BuOK / tetrahydrofuran / Ambient temperature 7: dimethylformamide / 80 °C 8: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 9: 68.7 percent / pyridine / 72 h / Ambient temperature 10: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 11: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 12: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 13: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: toluene / 1 h / 80 °C 2: pyridine / CHCl3 / Ambient temperature 3: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 4: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 5: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 6: 81 percent / pyridine / Ambient temperature 7: 99 percent / pyridine / CHCl3 / Ambient temperature 8: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 9: t-BuOK / tetrahydrofuran / Ambient temperature 10: dimethylformamide / 80 °C 11: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 12: 68.7 percent / pyridine / 72 h / Ambient temperature 13: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 14: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 15: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 16: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: H2 / 5percent Pd/C / tetrahydrofuran / Ambient temperature 2: phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 3: 66 percent / LiAlH4 / tetrahydrofuran / Ambient temperature 4: 81 percent / pyridine / Ambient temperature 5: 99 percent / pyridine / CHCl3 / Ambient temperature 6: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 7: t-BuOK / tetrahydrofuran / Ambient temperature 8: dimethylformamide / 80 °C 9: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 10: 68.7 percent / pyridine / 72 h / Ambient temperature 11: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 12: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 13: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 14: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme

1: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 2: 81 percent / pyridine / Ambient temperature 3: 99 percent / pyridine / CHCl3 / Ambient temperature 4: 81.5 percent / 1N HCl / dioxane / 1 h / Heating 5: t-BuOK / tetrahydrofuran / Ambient temperature 6: dimethylformamide / 80 °C 7: H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h 8: 68.7 percent / pyridine / 72 h / Ambient temperature 9: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 10: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 11: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 12: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme