Γ-O-十八烷基-L-Α-溶血卵磷脂合成路线 （共 45 条）
反应条件
1: 82.5 percent / dimethylsulfoxide / 0.5 h / 140 °C 2: 99.4 percent / H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h / Ambient temperature 3: 60 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 4: 61.8 percent / K2CO3 / methanol / 3 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 65, # 3 p. 1059 - 1084
反应条件
1: 81.5 percent / dimethylsulfoxide / 0.5 h / 140 °C 2: 68.5 percent / KOH / methanol; H2O / 0.5 h / Heating 3: 68.7 percent / pyridine / 72 h / Ambient temperature 4: 98.6 percent / NaH / dimethylformamide / 2 h / 80 °C 5: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 6: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 7: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 65, # 3 p. 1059 - 1084
反应条件
1: 99.4 percent / H2 / 5percent Pd/C / tetrahydrofuran / 0.25 h / Ambient temperature 2: 60 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 3: 61.8 percent / K2CO3 / methanol / 3 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 65, # 3 p. 1059 - 1084
反应条件
1: 88 percent / 1N HCl / dioxane / 1.5 h / 90 °C 2: 79 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 3: 100 percent / H2 / PdO / methanol; H2O / 1 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 65, # 3 p. 1059 - 1084
反应条件
1: 94 percent / KH (22percent) / benzene / 2 h / Heating 2: 95 percent / HCl (2N) / tetrahydrofuran / 3 h / Ambient temperature 3: 1.) Pb(OAc)4; 2.) NaBH4 / 1.) benzene, 2 h, room temp.; 2.) methanol, THF, room temp. 4: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h 5: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 6: 98 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
1: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 2: 98 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
1: 1.) Pb(OAc)4; 2.) NaBH4 / 1.) benzene, 2 h, room temp.; 2.) methanol, THF, room temp. 2: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h 3: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 4: 98 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
1: 95 percent / HCl (2N) / tetrahydrofuran / 3 h / Ambient temperature 2: 1.) Pb(OAc)4; 2.) NaBH4 / 1.) benzene, 2 h, room temp.; 2.) methanol, THF, room temp. 3: 1.) NEt3; 2.) KCl (0.1N) / 1.) CHCl3, room temp., 6h; 40 deg C, 12 h; 2.) 1 h 4: 2.) AgOAc / 1.) methanol, 55 deg C, overnight; 2.) 90 percent aqueous methanol, 2 h 5: 98 percent / H2 / palladium black / ethanol / 72 h / 50 °C / 760 Torr View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 33, # 2 p. 572 - 582
反应条件
potassium acetate in methanol 80 h; Heating;
参考文献
Cimetiere, B; Jacob, L; Julia, M
Bulletin de la Societe Chimique de France, 1991 , # 6 p. 926 - 938
反应条件
1: 60 percent / phosphorus oxychloride, Et3N, pyridine / CHCl3 / Ambient temperature 2: 61.8 percent / K2CO3 / methanol / 3 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 65, # 3 p. 1059 - 1084
