1: 80 percent / manganese (IV) oxide / CHCl3; methanol / 20 h / Ambient temperature 2: 73 percent / NaOMe / methanol / 2 h / -15 °C 3: 87 percent / xylene / 4 h / Heating 4: 85 percent / HCl / methanol / 6 h / Heating 5: 2.) HCl / 1.) CH2Cl2, room temp., 12 h; 2.) 12 h, ether 6: 1.) BBr3; 2.) MeOH, H2SO4 (96percent) / 1.) CH2Cl2, room temp., 140 h; 2.) reflux, 48 h 7: 93 percent / benzoyl t-butyl nitroxide / methanol; CHCl3 / 16 h / Ambient temperature View Scheme

1: 94 percent / ethanol / 3.5 h / 45 °C 2: 97 percent / potassium carbonate / acetone / 8 h / Heating 3: 98 percent / LiAlH4 / tetrahydrofuran / 2 h / 0 °C 4: 80 percent / manganese (IV) oxide / CHCl3; methanol / 20 h / Ambient temperature 5: 73 percent / NaOMe / methanol / 2 h / -15 °C 6: 87 percent / xylene / 4 h / Heating 7: 85 percent / HCl / methanol / 6 h / Heating 8: 2.) HCl / 1.) CH2Cl2, room temp., 12 h; 2.) 12 h, ether 9: 1.) BBr3; 2.) MeOH, H2SO4 (96percent) / 1.) CH2Cl2, room temp., 140 h; 2.) reflux, 48 h 10: 93 percent / benzoyl t-butyl nitroxide / methanol; CHCl3 / 16 h / Ambient temperature View Scheme

1: 1) KOH / 2) KI / 1) MeOH, r.t., 5 h, 2) r.t., 2 d 2: 91 percent / hydrogen / Raney-nickel / tetrahydrofuran / 32 h / 760 Torr / Ambient temperature 3: 96 percent / 3N HCl / methanol / 4 h / Heating 4: 1) Et3N, 2) air, HCl(g) / 2) Cu(OAc)2 / 1) CH2Cl2, 30 min, 2) CH2Cl2, 4 h 5: 84 percent / hydrogen / 5percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature 6: 81 percent / conc. HNO3 / acetic acid / 0.5 h / Ambient temperature View Scheme

1: 84 percent / hydrogen / 5percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature 2: 81 percent / conc. HNO3 / acetic acid / 0.5 h / Ambient temperature View Scheme

potassium carbonate in N,N-dimethyl-formamide T=25°C;

1: 75 percent / LiOH, H2O / tetrahydrofuran / 5 h / Ambient temperature 2: NH4OH / H2O / 0.5 h / Ambient temperature View Scheme

1: 100 percent / 0.05M Na2CO3 / H2O / 24 h / 30 °C 2: 84 percent / thiophenol / acetonitrile / 2 h View Scheme