74497-02-2合成路线 （共 11739 条）
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=-78 - 20°C; Further byproducts given;
参考文献
Koutentis, Panayiotis A.; Rees, Charles W.
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 2 p. 111 - 117
参考文献
Reissert; Brueggemann
Chemische Berichte, 1924 , vol. 57, p. 987
参考文献
Reissert; Brueggemann
Chemische Berichte, 1924 , vol. 57, p. 987
反应条件
1) toluene, reflux, 2) reflux; Multistep reaction;
参考文献
Woolston, C. R. J.; Lee, J. B.; Swinbourne, F. J.
Organic Mass Spectrometry, 1993 , vol. 28, # 4 p. 445 - 450
反应条件
1.1: hydrogenchloride; sodium nitrite / water / 0.25 h / 0 °C
1.2: 0.5 h / 0 °C
2.1: sodium acetate / ethanol; water / 20 - 80 °C
View Scheme
参考文献
Guru, Murali Mohan; Ali, Md Ashif; Punniyamurthy, Tharmalingam
Journal of Organic Chemistry, 2011 , vol. 76, # 13 p. 5295 - 5308
反应条件
1: carbon monoxide; 4-fluorophenyl boronic acid; methyl vinyl ketone With RhH(CO)(triphenylphosphine)3 in methanol
T=80°C; P=15001.2 Torr; 18 h;
2: aniline With iodine in tetrahydrofuran
T=40°C; Paal-Knorr cyclization;
参考文献
Chochois, Helene; Sauthier, Mathieu; Maerten, Eddy; Castanet, Yves; Mortreux, Andre
Tetrahedron, 2006 , vol. 62, # 50 p. 11740 - 11746
反应条件
(i) NaNO2, aq. HCl, (ii) /BRN= 511492/, NaOH; Multistep reaction;
参考文献
Garcia-Munoz,G. et al.
Journal of Heterocyclic Chemistry, 1977 , vol. 14, p. 427 - 430
反应条件
1: 1.) sodium nitrite, 6N HCl; 2.) sodium acetate / 1.) water; 2.) water, ethanol, 0 - 5 deg C, 3 h -> overnight
2: 63 percent / sodium ethoxide / diethyl ether / 15 h / Ambient temperature
View Scheme
参考文献
ALLA CHEM, LLC
Patent: US2011/53915 A1, 2011 ;
反应条件
1: hydrogenchloride; sodium nitrite / water / 0 °C
2: sodium acetate / ethanol; water / 1 h / 0 - 5 °C
3: sodium ethanolate / diethyl ether / 16 h / 20 °C
4: hydrazine hydrate / ethanol / 24 h / Boiling
View Scheme
参考文献
ALLA CHEM, LLC
Patent: US2011/53915 A1, 2011 ;
反应条件
1: Et2NH / diethyl ether / 0.5 h
2: 1.) aq. NaOH, 2.) Amberlyst*H(1+) / 1.) acetone, 5 min, 2.) MeOH
View Scheme
参考文献
Savignac,P.; Lavielle,G.
Bulletin de la Societe Chimique de France, 1974 , p. 1506 - 1508
