74497-02-2合成路线 （共 11739 条）
反应条件
1: 1) p-toluenesulfonic acid monohydrate, 2) NaBH4 / 1) toluene, 22 h, reflux, 2) ethanol, rt, 3 h 2: 10.04 g / toluene / 3 h / Heating View Scheme
参考文献
Brine; Boldt; Huang; Sawyer; Carroll
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 3 p. 677 - 686
反应条件
1: 32 percent / Br2; AcOH / 1 h / cooling 2: 85 percent / NH2NH2*H2O; NH2NH2*H2SO4 / ethane-1,2-diol / 2 h / 120 °C View Scheme
参考文献
Ouyang, Liang; Huang, Yuhui; Zhao, Yuwei; He, Gu; Xie, Yongmei; Liu, Jie; He, Jun; Liu, Bo; Wei, Yuquan
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3044 - 3049
反应条件
acetic acid in water; toluene 4 h; Heating;
参考文献
Ogawa, Toshihisa; Tomisawa, Kazuyuki; Sota, Kaoru
Heterocycles, 1988 , vol. 27, # 6 p. 1421 - 1430
反应条件
acetic acid in water; toluene 5 h; Ambient temperatureHeating;
参考文献
Ogawa; Tomisawa; Sota
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 6 p. 1609 - 1611
反应条件
in water; acetic acid; toluene Heating;
参考文献
Ogawa; Tomisawa; Sota
Chemical and Pharmaceutical Bulletin, 1988 , vol. 36, # 6 p. 1957 - 1962
反应条件
1.1: potassium carbonate; copper(II) oxide / Reflux 2.1: sulfuric acid / 4 h / Heating 3.1: sodium hydroxide / Heating 3.2: Reflux View Scheme
参考文献
Girdhar, Amit; Jain, Sandeep; Jain, Neelam; Girdhar, Shikha
Acta Poloniae Pharmaceutica - Drug Research, 2010 , vol. 67, # 2 p. 211 - 214
反应条件
hydrogen bromide in diethylene glycol T=170°C; 5 h;
参考文献
Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; et al.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1339 - 1349
反应条件
1: N-ethyl-N,N-diisopropylamine / 9 h / 20 - 60 °C 2: ethanol; ammonium chloride; zinc / 5 h / Reflux View Scheme
参考文献
Yoshino, Hiroshi; Ueda, Norihiro; Niijima, Jun; Sugumi, Hiroyuki; Kotake, Yoshihiko; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 13 p. 2496 - 2497
反应条件
1: 94 percent / KOH; Pd[P(t-Bu3)]2; cetyltrimethylammonium bromide / toluene; H2O / 3 h / 90 °C 2: 82 percent / KOH; Pd[P(t-Bu3)]2; cetyltrimethylammonium bromide / toluene; H2O / 24 h / 90 °C View Scheme
参考文献
Gujadhur, Rattan; Venkataraman; Kintigh, Jeremy T
Tetrahedron Letters, 2001 , vol. 42, # 29 p. 4791 - 4793
反应条件
tert.-butylnitrite; boron trifluoride diethyl etherate in acetonitrile T=50°C; Diazotization; Arylation; Trifluoromethylthiodediazoniation;
参考文献
Adams, Dave J.; Goddard, Andrew; Clark, James H.; Macquarrie, Duncan J.
Chemical Communications, 2000 , # 11 p. 987 - 988
