74497-02-2合成路线 （共 11739 条）
参考文献
Prelog; Stepan
Collection of Czechoslovak Chemical Communications, 1935 , vol. 7, p. 93,101
反应条件
1: aniline With hydrogenchloride; sodium nitrite in water T=0 - 5°C; 2: With sodium tetrafluoroborate in water 0.166667 h; 3: potassium p-ethylphenyltrifluoroborate With palladium diacetate; sodium carbonate in water T=25°C; Suzuki-Miyaura Coupling; 6 h;
参考文献
Tetrahedron Letters, , vol. 54, # 46 p. 6211 - 6214
反应条件
copper diacetate; potassium carbonate T=160°C; Ullmann Condensation; 1 h; Inert atmosphere;
参考文献
EP1940965 B1, ;
Paragraph 0105-0106 ;
反应条件
n-ethyl morpholine; copper; copper(l) chloride in various solvent(s) T=70°C; 15 h;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 5 p. 843 - 851
参考文献
Journal of the American Chemical Society, , vol. 45, p. 1914
反应条件
in tetrahydrofuran; hexane 1.) r.t., overnight, 2.) reflux, 2 h; Yield given;
参考文献
Kuo; Huang; Cheng; Ling; Wu; Ishii; Nakamura
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 955 - 963
反应条件
sodium; triethylamine Yield given. Multistep reaction;
参考文献
Yazima; Munakata
Agricultural and Biological Chemistry, 1980 , vol. 44, # 2 p. 235 - 243
反应条件
1: polyphosphoric acid / 16.75 h / 80 - 120 °C 2: phosphorus tribromide / N,N-dimethyl-formamide / 3 h / 0 - 20 °C 3: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C 4: selenium(IV) oxide / 1,4-dioxane / 2 h / 80 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 69, p. 527 - 536
反应条件
1: 4-(dihydroxyboryl)benzoic acid With N,N-diethanolaminomethyl polystyrene in tetrahydrofuran T=20°C; 1 h; 2: aniline With water; benzotriazol-1-ol; diisopropyl-carbodiimide T=20°C; 18 h; 3: in tetrahydrofuran; water T=20°C; 0.0166667 h; Further stages.;
参考文献
Gravel, Michael; Thompson, Kim A.; Zak, Mark; Berube, Christian; Hall, Dennis G.
Journal of Organic Chemistry, 2002 , vol. 67, # 1 p. 3 - 15
反应条件
nickel(II) ammonium disulfate; nitric acid in chloroform; water T=20°C; 4 h;
参考文献
Synthetic Communications, , vol. 31, # 7 p. 1123 - 1127
