74497-02-2合成路线 （共 11739 条）
反应条件
in diethyl ether
T=20°C; 16 h;
参考文献
Boeckel, C. A. A. van; Visser, G. M.; Hermans, J. P. G.; Boom, J. H. van
Recueil: Journal of the Royal Netherlands Chemical Society, 1983 , vol. 102, p. 526 - 537
参考文献
Moniot; Kravetz; El Rahman Abd El Rahman; Shamma
Journal of Pharmaceutical Sciences, 1979 , vol. 68, # 6 p. 705 - 708
反应条件
1.1: sulfur / 20 h / 270 °C
2.1: sodium hydroxide / N,N-dimethyl-formamide / 20 °C
2.2: 20 - 75 °C
View Scheme
参考文献
Galliford, Chris V.; Voronin, Kimberly; Hesk, David; Koharski, David; McNamara, Paul
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 5 p. 229 - 232
反应条件
1: zinc chloride / 230 - 240 °C
2: concentrated sulfuric acid; nitric acid / -5 - 5 °C
3: Diazotization.Verkochen mit Alkohol
View Scheme
参考文献
Reilly; Hickinbottom
Journal of the Chemical Society, 1920 , vol. 117, p. 133
反应条件
in dichloromethane
T=25°C; 24 h; Cooling with iceInert atmosphere;
参考文献
Fortin, Sebastien; Wei, Lianhu; Moreau, Emmanuel; Lacroix, Jacques; Cote, Marie-France; Petitclerc, Eric; Kotra, Lakshmi P.; Gaudreault, Rene C.
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5327 - 5342
反应条件
sodium hydroxide; sulfuric acid; bromine
1.) 15 h, 20 deg C, 2.) ice; Yield given. Multistep reaction;
参考文献
Gorelik, M. V.; Lomzakova, V. I.; Khamidova, E. A.; Shteiman, V. Ya.; Kuznetsova, M. G.; Andrievskii, A. M.
Russian Journal of Organic Chemistry, 1995 , vol. 31, # 4 p. 508 - 512
Zhurnal Organicheskoi Khimii, 1995 , vol. 31, # 4 p. 553 - 557
参考文献
Grohmann
Chemische Berichte, 1891 , vol. 24, p. 3814
反应条件
1: 1.)conc. HCl, NaNO2 2.) pyridine / 1.) water 2.) 0 deg C
2: 60 percent / BF3 / acetic acid / 0.17 h
3: 0.12 g / 30percent H2O2 / acetic acid / 96 h / Ambient temperature
View Scheme
参考文献
Atallah, Raja H.; Nazer, Musa Z.
Tetrahedron, 1982 , vol. 38, # 12 p. 1793 - 1796
反应条件
phenol
T=125 - 130°C; 7 h; var. phenol/2,2',4,4'-tetranitrobenzophenone ratios; other substituted anilines; Product distribution;
参考文献
Gorvin, John H.
Journal of Chemical Research, Miniprint, 1993 , # 10 p. 2779 - 2788
参考文献
Gorvin, John H.
Journal of Chemical Research, Miniprint, 1993 , # 10 p. 2779 - 2788
