74497-02-2合成路线 （共 11739 条）
反应条件
1: 2-amino-5-nitro-1,3-thiazole With sulfuric acid; acetic acid; propionic acid; sodium nitrite
T=10°C;
2: aniline T=5°C; 1 h;
参考文献
Kim, Ji-Hye; Lee, Jae-Yong; Bae, Ji-Hye; Choi, Jae-Hong
Molecular Crystals and Liquid Crystals, 2013 , vol. 583, # 1 p. 70 - 76
反应条件
1: EDCI; HOBt; DIEA / 9 h / 20 °C
2: aq. LiOH / ethanol / 3 h / 20 °C
View Scheme
参考文献
Anandan, Sampath-Kumar; Ward, John S.; Brokx, Richard D.; Bray, Mark R.; Patel, Dinesh V.; Xiao, Xiao-Xi
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 8 p. 1969 - 1972
反应条件
Edukt l ist ein Gemisch von monomerem und polymerem Azelainsaeure-anhydrid;
参考文献
Hill; Carothers
Journal of the American Chemical Society, 1933 , vol. 55, p. 5031,5034
参考文献
Suzuki, Takayoshi; Nagano, Yuki; Matsuura, Azusa; Kohara, Arihiro; Ninomiya, Shin-Ichi; Kohda, Kohfuku; Miyata, Naoki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4321 - 4326
反应条件
DBSA in water
T=23°C; Mannich reaction; 24 h;
参考文献
Manabe, Kei; Mori, Yuichiro; Kobayashi, Shu
Tetrahedron, 2001 , vol. 57, # 13 p. 2537 - 2544
反应条件
dihydrogen peroxide; 6-aminopurine in ethanol; water
T=20°C; Mannich reaction; 6 h; optical yield given as percent dechemoselective reaction;
参考文献
Kumar, Vishal; Sharma, Upendra; Verma, Praveen Kumar; Kumar, Neeraj; Singh, Bikram
Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 5 p. 639 - 645
反应条件
camphor-10-sulfonic acid in water
T=20°C; Mannich reaction; 24 h; Product distribution; Further Variations:Catalysts;
参考文献
Manabe, Kei; Kobayashi, Shu
Organic Letters, 1999 , vol. 1, # 12 p. 1965 - 1967
反应条件
in dichloromethane
1) 0 deg C, 2 h, 2) 20 deg C, 1 h;
参考文献
Mironova, A. A.; Soloshonok, I. V.; Maletina, I. I.; Orda, V. V.; Yagupol'skii, L. M.
Journal of Organic Chemistry USSR (English Translation), 1988 , vol. 24, # 3 p. 530 - 535
Zhurnal Organicheskoi Khimii, 1988 , vol. 24, # 3 p. 593 - 598
反应条件
1.1: potassium carbonate; copper / N,N-dimethyl-formamide / 130 °C
2.1: trichlorophosphate / 3 h / 130 °C
3.1: sodium hydride / tetrahydrofuran / 0.75 h / 20 °C
3.2: |Reflux
View Scheme
参考文献
Lang, Xuliang; Li, Lulu; Chen, Yuzong; Sun, Qinsheng; Wu, Qin; Liu, Feng; Tan, Chunyan; Liu, Hongxia; Gao, Chunmei; Jiang, Yuyang
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4170 - 4177
反应条件
1: 73 percent / Et3N / CH2Cl2 / 3.75 h / 0 - 5 °C
2: 39 percent / NH2OH*HCl, Et3N / ethanol / 4.5 h / Ambient temperature
View Scheme
参考文献
Patonay, Tamas; Patonay-Peli, Erzsebet; Zolnai, Laszlo; Mogyorodi, Ferenc
Synthetic Communications, 1996 , vol. 26, # 22 p. 4253 - 4265
