74497-02-2合成路线 （共 11739 条）
反应条件
1: 180 °C
2: 85 percent / Et3N; EDCI; HOBt / dimethylformamide
View Scheme
参考文献
Suzuki, Takayoshi; Nagano, Yuki; Matsuura, Azusa; Kohara, Arihiro; Ninomiya, Shin-Ichi; Kohda, Kohfuku; Miyata, Naoki
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4321 - 4326
反应条件
1: in ethanol
12 h; Heating;
2: With hydrogenchloride in water
3 h;
参考文献
Porcheddu, Andrea; Giacomelli, Giampaolo; Chighine, Alessandra; Masala, Simonetta
Organic Letters, 2004 , vol. 6, # 26 p. 4925 - 4927
反应条件
1: |Inert atmosphere
2: PIDA; caesium carbonate / 2,2,2-trifluoroethanol / 0.5 h / 0 °C
View Scheme
参考文献
Huang, Jinbo; He, Yimiao; Wang, Yong; Zhu, Qiang
Chemistry - A European Journal, 2012 , vol. 18, # 44 p. 13964 - 13967
反应条件
1.1: 76 percent / I2; aq. HCl / 4.5 h / 140 - 155 °C
2.1: 71 percent / KOH / dimethylsulfoxide / 0.5 h
3.1: LiClO4; bis(2,2,2-trichloroethyl) azodicarboxylate / diethyl ether / 0 - 55 °C
3.2: 51 percent / Zn; AcOH / acetone / 3 h / 20 °C
View Scheme
参考文献
Brown, Chad W.; Liu, Shengquan; Klucik, Jozef; Berlin, K. Darrell; Brennan, Patrick J.; Kaur, Devinder; Benbrook, Doris M.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1008 - 1017
反应条件
1: in dichloromethane
T=20°C; 0.5 h;
2: With pyridine in dichloromethane
T=20°C; 2 h;
参考文献
Kalogirou, Andreas S.; Koutentis, Panayiotis A.
Molecules, 2009 , vol. 14, # 7 p. 2356 - 2362
参考文献
Helmholz, Falko; Schroeder, Rita; Langer, Peter
Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 2005 , vol. 60, # 11 p. 1192 - 1196
反应条件
1: Et3N / tetrahydrofuran / 0 - 20 °C
2: toluene / Heating
View Scheme
参考文献
Langer, Peter; Helmholz, Falko; Schroeder, Rita
Synlett, 2003 , # 15 p. 2389 - 2391
反应条件
1: Et3N / tetrahydrofuran / 0 - 20 °C
2: 56 percent / toluene / Heating
View Scheme
参考文献
Langer, Peter; Helmholz, Falko; Schroeder, Rita
Synlett, 2003 , # 15 p. 2389 - 2391
反应条件
triethylamine; 3-diphenyloxyphosphinyl-2-oxazolidinone in acetonitrile
T=40°C; 0.5 h;
参考文献
Abdel-Aziz, Alaa A.-M.
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 5 p. 614 - 626
反应条件
triethylamine; 3-diphenyloxyphosphinyl-2-oxazolidinone in acetonitrile
T=40°C; 0.75 h;
参考文献
Abdel-Aziz, Alaa A.-M.
European Journal of Medicinal Chemistry, 2007 , vol. 42, # 5 p. 614 - 626
