74497-02-2合成路线 （共 11739 条）
反应条件
1: aniline With hydrogenchloride; sodium nitrite in water
T=0 - 5°C;
2: 3-(4-methoxyphenyl)-2-thioxo-1,3-thiazolidin-4-one With sodium acetate; potassium hydroxide in ethanol; water
T=0 - 5°C; pH=10 - 12;
参考文献
El-Sonbati; Diab; El-Bindary; Nozha
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2011 , vol. 83, # 1 p. 490 - 498
参考文献
Steinkopf
Journal fuer Praktische Chemie (Leipzig), 1910 , vol. <2> 81, p. 228
Full Text Show Details
Steinkopf; Juergens
Journal fuer Praktische Chemie (Leipzig), vol. 2, p. 83,456
反应条件
acid-stable chloroglyoxime;
参考文献
Steinkopf
Journal fuer Praktische Chemie (Leipzig), 1910 , vol. <2> 81, p. 228
Full Text Show Details
Steinkopf; Juergens
Journal fuer Praktische Chemie (Leipzig), 1911 , vol. <2>83, p. 455
Journal fuer Praktische Chemie (Leipzig), 1911 , vol. <2>84, p. 710
反应条件
N-ethyl-N,N-diisopropylamine in ethyl acetate
T=-30 - 20°C; 3 h;
参考文献
Asano, Shigehiro; Ban, Hitoshi
Heterocycles, 2008 , vol. 75, # 1 p. 183 - 188
反应条件
1: (E)-4-ethoxy-4-oxobut-2-enoic acid With 4-methyl-morpholine; isobutyl chloroformate in dichloromethane
T=-20°C; 0.5 h;
2: aniline in dichloromethane
T=20°C; 4 h; Further stages.;
参考文献
Goetz, Marion G.; James, Karen Ellis; Hansell, Elizabeth; Dvorak, Jan; Seshaadri, Amritha; Sojka, Daniel; Kopacek, Petr; McKerrow, James H.; Caffrey, Conor R.; Powers, James C.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 9 p. 2816 - 2832
参考文献
Tarbell; Leister
Journal of Organic Chemistry, 1958 , vol. 23, p. 1149,1151
反应条件
in diethyl ether; water
1 h; Ambient temperature;
参考文献
Adiwidjaja, Gunadi; Guenther, Horst; Voss, Juergen
Liebigs Annalen der Chemie, 1983 , # 7 p. 1116 - 1132
参考文献
Diels; Gollmann
Chemische Berichte, 1911 , vol. 44, p. 3164
反应条件
hydrogenchloride; sodium nitrite
1.) glacial AcOH, H2O, 0 - 5 deg C, 2.) pyridine, below 10 deg C - room temp.; Yield given. Multistep reaction;
参考文献
Kidwai; Negi; Gupta
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 11 p. 2363 - 2364
反应条件
hydrogenchloride; sodium nitrite
1.) glacial AcOH, H2O, 0 - 5 deg C, 2.) pyridine, below 10 deg C - room temp.; Yield given. Multistep reaction;
参考文献
Sathi; Gujrati; Nath; Agarwal; Bhargava; Shanker
Arzneimittel-Forschung/Drug Research, 1983 , vol. 33, # 9 p. 1218 - 1221
