74497-02-2合成路线 （共 11739 条）
参考文献
Larizza; Brancaccio
Gazzetta Chimica Italiana, 1959 , vol. 89, p. 2402,2404
参考文献
Zav'yalov, S. I.; Zavozin, A. G.; Dorofeeva, O. V.; Rumyantseva, E. E.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1991 , vol. 40, # 2.2 p. 441 - 443
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1991 , vol. 40, # 2 p. 509 - 511
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran
T=20°C; 16 h;
参考文献
Norager, Niels Gron; Juhl, Karsten
Synthesis, 2010 , # 24 art. no. T15710SS, p. 4273 - 4281
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; HATU in acetonitrile
T=20°C; 25 h;
参考文献
ARRAY BIOPHARMA INC.; GENENTECH, INC.; GRINA, Jonas; HANSEN, Joshua D.; LAIRD, Ellen; MATHIEU, Simon; MORENO, David; REN, Li; RUDOLPH, Joachim; WENGLOWSKY, Steven Mark
Patent: WO2012/118492 A1, 2012 ;
Location in patent: Page/Page column 80 ;
WO 2012/118492 A1
反应条件
1: ethyl acetate / 4 h / 90 °C / |Microwave irradiation
2: toluene-4-sulfonic acid / dichloromethane / 6 h / |Reflux; |Darkness
3: N-bromosuccinmide / chloroform / 50 °C
View Scheme
参考文献
Cabrera-Rivera, Fanny A.; Ortiz-Nava, Claudia; Roman-Bravo, Perla; Escalante, Jaime; Leyva, Marco A.
Heterocycles, 2012 , vol. 85, # 9 p. 2173 - 2195,23
反应条件
1: iodine / ethanol / |Reflux
2: toluene-4-sulfonic acid; di-tert-butyl peroxide / 20 h / 110 °C / |Schlenk technique
View Scheme
参考文献
Zhao, Dan; Wang, Teng; Li, Jian-Xin
Chemical Communications, 2014 , vol. 50, # 49 p. 6471 - 6474
反应条件
mercury(II) oxide in benzene
0.5 h;
参考文献
Chaaban, I.; El-Kersh, M. A.
Pharmazie, 1984 , vol. 39, # 3 p. 183 - 184
参考文献
Wasa, Masayuki; Worrell, Brady T.; Yu, Jin-Quan
Angewandte Chemie - International Edition, 2010 , vol. 49, # 7 p. 1275 - 1277
反应条件
toluene-4-sulfonic acid in toluene
T=35°C; 24 h;
参考文献
Calestani, Gianluca; Capella, Laura; Leardini, Rino; Minozzi, Matteo; Nanni, Daniele; Papa, Romina; Zanardi, Giuseppe
Tetrahedron, 2001 , vol. 57, # 33 p. 7221 - 7233
参考文献
Jiang, Faqin; Weng, Qinjie; Sheng, Rong; Xia, Qing; He, Qiaojun; Yang, Bo; Hu, Yongzhou
Archiv der Pharmazie, 2007 , vol. 340, # 5 p. 258 - 263
