74497-02-2合成路线 （共 11739 条）
参考文献
Gwizdala, Celina; Singh, Charlene V.; Friss, Tracey R.; MacDonald, John C.; Burdette, Shawn C.
Dalton Transactions, 2012 , vol. 41, # 26 p. 8162 - 8174
反应条件
(i) SOCl2, (ii) /BRN= 605631/, CHCl3; Multistep reaction;
参考文献
Melandri,M. et al.
Bollettino Chimico Farmaceutico, 1963 , vol. 102, p. 777 - 783
参考文献
Maruoka, Hiroshi; Okabe, Fumi; Yamagata, Kenji
Journal of Heterocyclic Chemistry, 2007 , vol. 44, # 1 p. 201 - 203
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
Wyeth
Patent: US2007/72897 A1, 2007 ;
Location in patent: Page/Page column 86 ;
反应条件
1: With acetic acid in dichloromethane
T=20°C; 24 h;
2: With sodium tris(acetoxy)borohydride in dichloromethane
T=20°C; 24 h;
参考文献
CHIESI FARMACEUTICI S.P.A.; AMARI, Gabriele; ARMANI, Elisabetta; RICCABONI, Mauro; RIZZI, Andrea; BAKER-GLENN, Charles; BLACKABY, Wesley; VAN DE PÖEL, Hervé; WHITTAKER, Ben
Patent: WO2014/86852 A1, 2014 ;
Location in patent: Page/Page column 70; 71 ;
反应条件
1: water / 35 - 40 °C
2: sodium amalgam; alcohol
View Scheme
参考文献
Bamberger; Mueller
Justus Liebigs Annalen der Chemie, 1900 , vol. 313, p. 118
反应条件
acetic acid
0.5 h; Heating;
参考文献
Caswell; Guevara; Corley; Martinez; Hollis; Largess; Thornley
Synthesis, 1992 , # 9 p. 823 - 825
参考文献
Pratt; Perkins
Journal of the American Chemical Society, 1918 , vol. 40, p. 230
反应条件
tert.-butylnitrite; toluene-4-sulfonic acid in 1,2-dichloro-ethane
T=0°C; Sandmeyer Reaction; 4 h; Inert atmosphere;
参考文献
Qiu, Di; Meng, He; Jin, Liang; Wang, Shuai; Tang, Shengbo; Wang, Xi; Mo, Fanyang; Zhang, Yan; Wang, Jianbo
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11581 - 11584
Angew. Chem., 2013 , vol. 125, # 44 p. 11795 - 11798
参考文献
Ponci,R. et al.
Farmaco, Edizione Scientifica, 1964 , vol. 19, p. 356 - 376
