1-叔丁氧羰基-4-(4-氨基丁基)哌嗪合成路线 （共 3 条）
反应条件
hydrazine hydrate in ethanol
8 h; Heating;
参考文献
GE HEALTHCARE LIMITED; MEDI-PHYSICS, INC.; NEWINGTON, Ian, Martin; WYNN, Duncan George; NAIRNE, Robert James Domett; GUILBERT, Benedicte; MANDAL, Subrata; JINTO, Jose; VARADARAJAN, Sunderaraman; RANGASWAMY, Chitralekha; BETTS, Helen; DAVIS, Rebecca
Patent: WO2011/150183 A1, 2011 ;
Location in patent: Page/Page column 170; 172 ;
WO 2011/150183 A1
反应条件
1: 95 percent / DIPEA / acetonitrile / 12 h / Heating
2: 100 percent / hydrazine monohydrate / ethanol / 8 h / Heating
View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
反应条件
1: 75 percent / CH2Cl2 / 20 °C
2: 95 percent / DIPEA / acetonitrile / 12 h / Heating
3: 100 percent / hydrazine monohydrate / ethanol / 8 h / Heating
View Scheme
参考文献
Tahtaoui, Chouaib; Parrot, Isabelle; Klotz, Philippe; Guillier, Fabrice; Galzi, Jean-Luc; Hibert, Marcel; Ilien, Brigitte
Journal of Medicinal Chemistry, 2004 , vol. 47, # 17 p. 4300 - 4315
