bis(norbornadiene)rhodium(I) tetrafluoroborate; (R)-(S)-MOD-Mandyphos in methanol; toluene T=20 - 30°C; P=37503.8 Torr; 19 h;

bis(norbornadiene)rhodium(I) tetrafluoroborate; (R)-(S)-MOD-Mandyphos; hydrogen; triethylamine in methanol T=20°C; P=4380.18 Torr; 4 h; Inert atmosphereAutoclave; optical yield given as percent eeenantioselective reaction;

Oxonetrade; in water; isopropyl alcohol T=20°C; 18 h;

1.1: triethylamine; methanesulfonyl chloride / toluene / 2.5 h / 5 - 25 °C 1.2: 4 h / 60 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -5 °C 2.2: 3.25 h / -5 - 20 °C 3.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 50 °C 4.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 25 °C 5.1: triethylamine / toluene / 2 h / -10 °C 6.1: dihydrogen peroxide; lithium hydroxide hydrate / methanol; water / 1 h / -10 °C 6.2: -10 - 20 °C View Scheme

1.1: AlCl3, aluminium chloride / chlorobenzene / 4 h / 30 °C 2.1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 8 h / 35 °C 3.1: oxone® / acetone; tetrahydrofuran; water / 3.5 h / 20 - 30 °C 4.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -5 °C 4.2: 3.25 h / -5 - 20 °C 5.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 50 °C 6.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 25 °C 7.1: triethylamine / toluene / 2 h / -10 °C 8.1: dihydrogen peroxide; lithium hydroxide hydrate / methanol; water / 1 h / -10 °C 8.2: -10 - 20 °C View Scheme

1.1: oxone® / acetone; tetrahydrofuran; water / 3.5 h / 20 - 30 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -5 °C 2.2: 3.25 h / -5 - 20 °C 3.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 50 °C 4.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 25 °C 5.1: triethylamine / toluene / 2 h / -10 °C 6.1: dihydrogen peroxide; lithium hydroxide hydrate / methanol; water / 1 h / -10 °C 6.2: -10 - 20 °C View Scheme

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -5 °C 1.2: 3.25 h / -5 - 20 °C 2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 50 °C 3.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 25 °C 4.1: triethylamine / toluene / 2 h / -10 °C 5.1: dihydrogen peroxide; lithium hydroxide hydrate / methanol; water / 1 h / -10 °C 5.2: -10 - 20 °C View Scheme

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -5 °C 1.2: 3.25 h / -5 - 20 °C 2.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 50 °C 3.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 25 °C 4.1: triethylamine / toluene / 2 h / -10 °C 5.1: dihydrogen peroxide; lithium hydroxide hydrate / methanol; water / 1 h / -10 °C 5.2: -10 - 20 °C View Scheme

1.1: sodium hydroxide; water / tetrahydrofuran / 3 h / 50 °C 2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 18 h / 25 °C 3.1: triethylamine / toluene / 2 h / -10 °C 4.1: dihydrogen peroxide; lithium hydroxide hydrate / methanol; water / 1 h / -10 °C 4.2: -10 - 20 °C View Scheme

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 20 °C / Large scale reaction 1.2: 0 - 20 °C / Large scale reaction 2.1: bis(norbornadiene)rhodium(I) tetrafluoroborate; (R)-(S)-MOD-Mandyphos; hydrogen; triethylamine / methanol / 4 h / 20 °C / 4380.18 Torr / Inert atmosphere; Autoclave View Scheme