(R)-2-(4-环丙烷磺酰基苯基)-3-(四氢吡喃-4-基)丙酸合成路线 （共 11 条）
反应条件
1.1: AlCl3, aluminium chloride / dichloromethane / 0 - 5 °C / Large scale reaction
1.2: 2 h / 0 - 5 °C / Large scale reaction
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / 0 - 20 °C / Large scale reaction
2.2: 0 - 20 °C / Large scale reaction
3.1: bis(norbornadiene)rhodium(I) tetrafluoroborate; (R)-(S)-MOD-Mandyphos; hydrogen; triethylamine / methanol / 4 h / 20 °C / 4380.18 Torr / Inert atmosphere; Autoclave
View Scheme
参考文献
Magnus, Nicholas A.; Braden, Timothy M.; Buser, Jonas Y.; Debaillie, Amy C.; Heath, Perry C.; Ley, Christopher P.; Remacle, Jacob R.; Varie, David L.; Wilson, Thomas M.
Organic Process Research and Development, 2012 , vol. 16, # 5 p. 830 - 835
